MORPHOLOGICAL AND BIOCHEMICAL STUDIES OF ISOLATED MITOCHONDRIA FROM FETAL, NEONATAL, AND ADULT LIVER AND FROM NEOPLASTIC TISSUES
| Autor: | David H. Yawn, Zack R. Blailock, Helen A. Mintz, Arnold Schwartz, Brian Safer, Annabel G. Liebelt, Erwin R. Rabin, Edward Bresnick |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
Biological Transport Active chemistry.chemical_element Calcium Biology Mitochondrion Article Andrology Valinomycin chemistry.chemical_compound Fetus Oxygen Consumption Pregnancy Edema medicine Animals Isolated mitochondria Mammary tumor Mammary Neoplasms Experimental Cell Biology Anti-Bacterial Agents Mitochondria Rats Microscopy Electron Animals Newborn Liver chemistry Immunology Potassium Female Adult liver medicine.symptom |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.34.2.513 |
| Popis: | A combined morphological and biochemical investigation of mitochondria from developing and rapidly growing tissues ( tumors, fetal, and very early neonatal rat liver) revealed mitochondria which were deficient in respiratory control, showed no valinomycin induced K+ accumulation or spontaneous Ca++ uptake, and were unable to undergo a swelling-contraction cycle. Electron microscopic examination of fetal and neonatal livers and a mammary tumor revealed mitochondria which differed from controls with respect to matrix density and ability to undergo reversible structural changes. The importance of isolation and assay media in interpretation of results is emphasized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|