Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
| Autor: | Gerd-Marie Alenius, Kristina Juneblad, Martin Johansson, Solbritt Rantapää-Dahlqvist |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Genotype Immunology Psoriatic Arthritis Single-nucleotide polymorphism Polymorphism Single Nucleotide PTPN22 Psoriatic arthritis Rheumatology Rheumatoid Factor Psoriasis Internal medicine medicine Immunology and Allergy Humans SNP Rheumatoid factor Genetic Predisposition to Disease Rheumatology and Autoimmunity Reumatologi och inflammation business.industry Arthritis Psoriatic Single Nucleotide Polymorphism Rs2476601 Protein Tyrosine Phosphatase Non-Receptor Type 22 Middle Aged medicine.disease Risk Allele Case-Control Studies Female business Research Article |
| Zdroj: | Arthritis Research & Therapy |
| Popis: | INTRODUCTION: The purpose of the present study was to investigate the frequency of the PTPN22 +1858 C/T single nucleotide polymorphism (SNP) (rs 2476601), previously shown to be associated with several autoimmune diseases, in patients with psoriatic arthritis (PsA) in comparison with population based controls. METHODS: A total of 291 patients (145 male/146 female, mean age (± S.D.) 52.2 (± 13.1) years) with PsA were examined clinically, by standard laboratory tests and their DNA was genotyped for the SNP rs2476601 (PTPN22 +1858 C/T). Allelic frequencies were determined and compared with 725 controls. RESULTS: Carriage of the risk allele, PTPN22+1858T, showed a significant association with patients with PsA compared with controls (χ2 = 6.56, P = 0.010, odds ratio (OR) 1.49; 95% confidence interval (CI) 1.10 to 2.02). A significantly higher proportion of carriers of the risk allele (T) had significantly more deformed joints (n ± SEM) (5.9 ± 1.2 vs 2.8 ± 0.5; P = 0.005). CONCLUSIONS: In this study the +1858T allele of the PTPN22 gene, known to be associated with several autoimmune diseases, was associated with PsA. The finding of significantly more joints with deformities among carriers of the T variant could indicate a more aggressive phenotype of disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|