Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme

Autor: Monique Groenewold, Douglas Gilliland, Peter Kearns, Agnieszka Mech, Maaike Visser, Hubert Rauscher, Kirsten Rasmussen, Mar González, Juan Riego Sintes, Eric A.J. Bleeker, Kenneth Moss
Rok vydání: 2018
Předmět:
FFF
Field flow fractionation

NMR
Nuclear magnetic resonance

AFM
Atomic force microscopy

EPR
electron paramagnetic resonance

Computer science
WAXS
Wide angle X-ray scattering

NM
nanomaterial

OECD
Organisation for Economic Co-operation and Development

SP
Single particle

VS
Vortex shaker method

POM
Polarised Light Optical Microscopy

(U)SAXS
(Ultra)Small Angle X-ray Scattering

02 engineering and technology
OECD test guidelines
JRC
European Commission's Joint Research Centre

MWCNT
multi-walled carbon nanotube

Toxicology
01 natural sciences
SMPS
Scanning mobility particle spectrometry

BET
Brunauer-Emmett-Teller method. BJH

UV-vis
Ultra violet-visible

ATOF-MS
Aerosol time-of-flight mass spectrometry

Barrett-Joyner-Halenda method
CEN

SEM
Scanning electron microscopy

FTIR
Fourier-transform infrared spectroscopy

Organisation for Economic Co-Operation and Development
TGP
OECD Test Guidelines Programme

Centrifugal liquid sedimentation
CNT

EDX (EDS)
Energy Dispersive X-ray spectrometry

SD
small drum method

Characterisation
SSA
specific surface area

General Medicine
3D
three dimensional

021001 nanoscience & nanotechnology
Manufactured nanomaterials
SDR
Sensor disk reader

SWCNT
single-walled carbon nanotube

ELS
Electrophoretic light scattering

Dynamic light scattering
DOSY NMR

ORP
oxidation
reduction potential

ESR
electron spin resonance

XRD
X-ray diffraction

0210 nano-technology
2D
two dimensional

ICP
Inductively coupled plasma

DTA
Differential thermal analysis

Nanotechnology
ISO
International Organisation for Standardisation

STM
Scanning tunnelling microscopy

010402 general chemistry
Article
GD
guidance document

Physico-chemical properties
ROS
reactive oxygen species

SAXS
Small angle X-ray scattering

XRF
X-ray fluorescence

XPS
X-ray photoelectron spectroscopy

Humans
OES
Optical emission spectrophotometry

Relevance (information retrieval)
Particle Size
European Committee for Standardisation
CLS

TEM
transmission electron microscopy

EM
electron microscopy

TG
OECD Test Guideline

WPMN
OECD Working Party on Manufactured Nanomaterials

Water
Diffusion ordered spectroscopy nuclear magnetic resonance. DSC
differential scanning calorimetry

AES
Auger electron spectroscopy

MALS
Multi-angle light scattering

Nanostructures
0104 chemical sciences
MS
mass spectrometry

ToF-SIMS
Time-of-flight Secondary Ion Mass Spectrometry

Working party on manufactured nanomaterials
Carbon nanotube
DLS

Biochemical engineering
SIMS
Secondary ion mass spectrometry
Zdroj: Regulatory Toxicology and Pharmacology
ISSN: 0273-2300
DOI: 10.1016/j.yrtph.2017.10.019
Popis: Identifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equivalent to those for nanomaterials. However, regulatory agencies lack an authoritative decision framework for nanomaterials that links the relevance of certain physico-chemical endpoints to toxicological effects. This paper investigates various physico-chemical endpoints and available test methods that could be used to produce such a decision framework for nanomaterials. It presents an overview of regulatory relevance and methods used for testing fifteen proposed physico-chemical properties of eleven nanomaterials in the OECD Working Party on Manufactured Nanomaterials' Testing Programme, complemented with methods from literature, and assesses the methods' adequacy and applications limits. Most endpoints are of regulatory relevance, though the specific parameters depend on the nanomaterial and type of assessment. Size (distribution) is the common characteristic of all nanomaterials and is decisive information for classifying a material as a nanomaterial. Shape is an important particle descriptor. The octanol-water partitioning coefficient is undefined for particulate nanomaterials. Methods, including sample preparation, need to be further standardised, and some new methods are needed. The current work of OECD's Test Guidelines Programme regarding physico-chemical properties is highlighted.
Highlights • Discussion of methods used for generating the OECD WPMN data on physico-chemical properties. • Indication of relevance of each physico-chemical endpoint and availability of adequate methods to investigate the endpoints. • Identification of areas for revision/new development of OECD Test Guidelines or Guidance Documents.
Databáze: OpenAIRE