Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate

Autor: Sanne J.M. Zilver, Christianne J.M. de Groot, Marloes Grobben, Sharon Remmelzwaal, Esmee Burgers, Daniela Nunez Velasco, Hannah G. Juncker, Britt J. van Keulen, Johannes B. van Goudoever, Robert A. de Leeuw, Marit J. van Gils, Carrie Ris-Stalpers, Elisabeth van Leeuwen
Přispěvatelé: Graduate School, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Paediatrics, Neonatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, General Paediatrics, Obstetrics and Gynaecology, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, APH - Methodology
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Infectious Diseases, 130, 126-135. Elsevier
Zilver, S J M, de Groot, C J M, Grobben, M, Remmelzwaal, S, Burgers, E, Velasco, D N, Juncker, H G, van Keulen, B J, van Goudoever, J B, de Leeuw, R A, van Gils, M J, Ris-Stalpers, C & van Leeuwen, E 2023, ' Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate ', International Journal of Infectious Diseases, vol. 130, pp. 126-135 . https://doi.org/10.1016/j.ijid.2023.02.022
ISSN: 1201-9712
Popis: Objectives: Preventive measures against COVID-19 are essential for pregnant women. Pregnant women are particularly vulnerable to emerging infectious pathogens due to alterations in their physiology. We aimed to determine the optimum timing of vaccination to protect pregnant women and their neonates from COVID-19. Methods: A prospective observational longitudinal cohort study in pregnant women who received COVID-19 vaccination. We collected blood samples to evaluate levels of antispike, receptor binding domain and nucleocapsid antibodies against SARS-CoV-2 before vaccination and 15 days after the first and second vaccination. We determined the neutralizing antibodies from mother-infant dyads in maternal and umbilical cord blood at birth. If available, immunoglobulin A was measured in human milk. Results: We included 178 pregnant women. Median antispike immunoglobulin G levels increased significantly from 1.8 to 5431 binding antibody units/ml and receptor binding domain from 6 to 4466 binding antibody units/ml. Virus neutralization showed similar results between different weeks of gestation at vaccination (P >0.3). Conclusion: We advise vaccination in the early second trimester of pregnancy for the optimum balance between the maternal antibody response and placental antibody transfer to the neonate.
Databáze: OpenAIRE
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