The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions

Autor: Canan Sadullahoğlu, Döndü Nergiz, Mehmet Tahir Oruç, Hülya Tosun Yıldırım, Cem Sezer, Alper Sayiner, Dinç Süren
Rok vydání: 2019
Předmět:
0301 basic medicine
Microbiology (medical)
Adult
Male
Pathology
medicine.medical_specialty
endocrine system
Adenoma
endocrine system diseases
Adolescent
lcsh:QR1-502
Thyroid Gland
Context (language use)
Malignancy
lcsh:Microbiology
Pathology and Forensic Medicine
Thyroid carcinoma
03 medical and health sciences
Young Adult
0302 clinical medicine
Poorly Differentiated Thyroid Carcinoma
Antigens
Neoplasm
Follicular phase
Adenocarcinoma
Follicular
medicine
lcsh:Pathology
Humans
TROP-2
Thyroid Neoplasms
Aged
Aged
80 and over
business.industry
Thyroid
General Medicine
Middle Aged
medicine.disease
thyroid carcinoma
Immunohistochemistry
Carcinoma
Neuroendocrine
030104 developmental biology
medicine.anatomical_structure
Medullary carcinoma
Thyroid Cancer
Papillary
030220 oncology & carcinogenesis
Female
Follicular neoplasm
business
Cell Adhesion Molecules
lcsh:RB1-214
Zdroj: Indian Journal of Pathology and Microbiology, Vol 62, Iss 2, Pp 206-210 (2019)
ISSN: 0974-5130
Popis: Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Subjects and Methods: This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases. Results: The cases comprised 32 (21%) males and 120 (79%) females with a mean age of 46.8 years (range, 15-85 years). TROP-2 expression was observed in 74.6% of the malignant lesions of the thyroid except for medullary carcinoma, poorly differentiated and undifferentiated thyroid carcinoma. Immunoreactivity was 3.4% in FA, 41.7% of cases with FTC and 81.8% in PTC follicular variant (PTC fv). The difference between FA/FTC and FA/PTC follicular variant were both significant (P < 0.005, P < 0.001, respectively). There was no difference between FTC/PTC fv (P = 0.089). Conclusion: TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid.
Databáze: OpenAIRE
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