Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry

Autor:	Tachapong Ngarmukos, Jasper Tromp, Tiew-Hwa Katherine Teng, Carolyn S.P. Lam, Michael R. MacDonald, Eugenio B. Reyes, Chanchal Chandramouli, Wan Ting Tay, Inder S. Anand, Bambang Budi Siswanto, Limin Yan, Judith G. Regensteiner, A. Mark Richards, Jonathan Yap, Cheuk-Man Yu, Chung-Lieh Hung, Lieng H. Ling
Přispěvatelé:	Cardiovascular Centre (CVC)
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Male medicine.medical_specialty Asia Heart failure Comorbidity 030204 cardiovascular system & hematology DISEASE 03 medical and health sciences MELLITUS 0302 clinical medicine Sex Factors Risk Factors QUALITY-OF-LIFE Internal medicine Diabetes mellitus Sex differences medicine Diabetes Mellitus Humans Mass index Aged ASSOCIATIONS RISK OUTCOMES Ejection fraction business.industry Hazard ratio Diabetes WOMEN Stroke Volume Odds ratio Middle Aged medicine.disease PREVALENCE Hospitalization Death Sudden Cardiac Echocardiography Lean body mass Cardiology Quality of Life Female GENDER Cardiology and Cardiovascular Medicine business SUDDEN CARDIAC DEATH Kidney disease
Zdroj:	European Journal of Heart Failure, 21(3), 297-307. Wiley
ISSN:	1879-0844 1388-9842
Popis:	Aims To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM).Methods and results Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 +/- 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were stratified by DM status to address the research aims. Despite similar prevalence of DM between Asian men (43%) and women (42%), the odds of DM increased at lower body mass index in women vs. men (>= 23 vs. >= 27.5 kg/m(2), P-interaction = 0.014). DM was more strongly related to chronic kidney disease in women vs. men [adjusted odds ratio (OR) 1.85, 95% confidence interval (CI) 1.33-2.57 vs. OR 1.32, 95% CI 1.11-1.56, P-interaction = 0.009]. Sex also modified the relationship between DM and left ventricular geometry (P-interaction = 0.003), whereby DM was associated with amore concentric left ventricular geometry in women than men. Women had lower quality of life than men (P Conclusions Asian women with HFrEF were more likely to have DM despite a lean body mass index, a greater burden of chronic kidney disease and more concentric left ventricular geometry, compared to men. Furthermore, DM confers worse quality of life, irrespective of sex, and a greater risk of adverse outcomes in women than men. These data underscore the need for sex-specific approaches to diabetes in patients with HF.
Databáze:	OpenAIRE
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