Interaction between amphetamine and α2-postsynaptic adrenoreceptors in the rat submaxillary gland
| Autor: | Mónica L. Fiszman, Francisco J.E. Stefano, J. C. Elverdin, C. J. Perec |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Submandibular Gland Inhibitory postsynaptic potential Postsynaptic potential Internal medicine medicine Animals Drug Interactions Amphetamine Pharmacology Dose-Response Relationship Drug Chemistry General Neuroscience Rats Inbred Strains Receptors Adrenergic alpha Reserpine Rats Clonidine Atropine Endocrinology Female Methacholine Guanabenz Adrenergic alpha-Agonists medicine.drug |
| Zdroj: | Journal of Autonomic Pharmacology. 7:199-204 |
| ISSN: | 1365-2680 0144-1795 |
| DOI: | 10.1111/j.1474-8673.1987.tb00149.x |
| Popis: | 1 The interaction between amphetamine and the alpha 2-adrenoreceptor agonists, clonidine and guanabenz, was studied in the submaxillary gland of anaesthetised rats. 2 Low doses of clonidine (10 micrograms/kg) and guanabenz (10 micrograms/kg) inhibited the secretory responses induced by methacholine and substance P, respectively. 3 Amphetamine (300 micrograms/kg) antagonized the inhibitory effects of both alpha 2-agonists. This dose of amphetamine alone did not show sialagogic effects. 4 Atropine (1 micrograms/kg) diminished the secretory responses to methacholine as much as clonidine (10 micrograms/kg). Amphetamine did not modify the blockade by atropine. 5 Guanabenz (10 micrograms/kg) markedly decreased the secretory responses to substance P, an effect that was also prevented by amphetamine. 6 Reserpine pretreatment (5 mg/kg, i.p., 18 h) did not alter the effect of amphetamine. 7 These results indicate that the interaction between amphetamine and alpha 2-adrenoreceptor agonists is unrelated to the indirect effect of this amine and suggest a direct interaction between the drug and postsynaptic inhibitory alpha 2-adrenoreceptors. |
| Databáze: | OpenAIRE |
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