Anti-AIDS Agents, 9. Suberosol, a New C31 Lanostane-Type Triterpene and Anti-HIV Principle from Polyalthia suberosa
| Autor: | James V. Snider, L. Mark Cosentino, Hui Ying Li, Nan Jun Sun, Kuo Hsiung Lee, Li Sun, Yoshiki Kashiwada |
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| Rok vydání: | 1993 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry HIV Core Protein p24 Human immunodeficiency virus (HIV) Pharmaceutical Science Biology Pharmacognosy medicine.disease_cause Antiviral Agents Lanostane Analytical Chemistry chemistry.chemical_compound Triterpene Drug Discovery medicine Humans Lymphocytes Cells Cultured Pharmacology chemistry.chemical_classification Polyalthia suberosa Plants Medicinal Anti hiv Organic Chemistry biology.organism_classification Terpenoid Complementary and alternative medicine chemistry Annonaceae HIV-1 Molecular Medicine Steroids |
| Zdroj: | Journal of Natural Products. 56:1130-1133 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50097a017 |
| Popis: | A new C31 lanostane-type triterpene, assigned the trivial name suberosol [1], has been isolated from Polyalthia suberosa as an anti-HIV principle. The structure has been characterized as 24-methylenelanost-7,9(11)-diene-3 beta, 15 alpha-diol (suberosol) [1], based on spectroscopic evidence. Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 micrograms/ml. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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