Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

Autor: Jae Myung Park, Chul-Hyun Lim, Jin Su Kim, Young-Seok Cho, Yu Kyung Cho, In Seok Lee, Myung-Gyu Choi, Myong Ki Baeg, Bo-In Lee, Sun-Hye Ko
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Reduced risk
Sarcopenia
Health Status
Health Behavior
Gastroenterology
Quality of life
Risk Factors
eradication
Prevalence
bioelectrical impedance analysis
Prospective Studies
Prospective cohort study
Original Research
Aged
80 and over
Hematologic Tests
biology
Age Factors
sarcopenia
Helicobacter pylori
bioelectrical impedanceanalysis
General Medicine
Middle Aged
musculoskeletal system
Female
Ghrelin secretion
Adult
medicine.medical_specialty
Adverse outcomes
macromolecular substances
Helicobacter Infections
Internal medicine
Republic of Korea
medicine
Humans
Body Weights and Measures
Muscle
Skeletal
Aged
business.industry
medicine.disease
Skeletal muscle mass
biology.organism_classification
body regions
Endocrinology
Socioeconomic Factors
Clinical Interventions in Aging
Quality of Life
Geriatrics and Gerontology
business
human activities
Zdroj: Clinical Interventions in Aging
CLINICAL INTERVENTIONS IN AGING(10)
ISSN: 1178-1998
Popis: Myong Ki Baeg, Myung-Gyu Choi, Sun-Hye Ko, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Young-Seok Cho, Bo-In Lee, In-Seok LeeDepartment of Internal Medicine, TheCatholic University of Korea College of Medicine, Seoul, Republicof KoreaBackground: Sarcopenia is associated with adverse outcomes such as physical disability, poorer quality of life, and death. Helicobacter pylori (HP) eradication increases ghrelin secretion, which may be a possible treatment for sarcopenia. We investigated whether HP eradication reduces the risk of low muscle mass (LMM), which is an integral component of sarcopenia.Materials and methods: Healthy, asymptomatic women aged ≥60 years who participated in a health screening program were enrolled. Subjects with a history of HP eradication were compared with those who were HP IgG+, but had not received HP-eradicating therapy. Body composition was measured by multifrequency bioelectrical impedance analysis. LMM was defined as body muscle mass 2 standard deviations below the mean muscle mass of healthy women aged 20–39 years from the same program. Multivariable analysis was used to identify sarcopenia risk factors.Results: Three hundred seventy-two women had received HP eradication, while 689 HP IgG+ women had not. The prevalence of LMM was significantly lower in those who received HP eradication (13.7% vs 21.6%, P=0.002). Multivariable analysis identified risk factors for LMM as age, white blood cell count, serum total protein concentration, and the metabolic syndrome. HP eradication (odds ratio: 0.632, 95% confidence interval: 0.440–0.824, P=0.013) was a significant preventive factor, and exercise (odds ratio: 0.710, 95% confidence interval: 0.504–1.002, P=0.051) had a preventive tendency.Conclusion: HP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia.Keywords: sarcopenia, Helicobacter pylori, eradication, bioelectrical impedance analysis
Databáze: OpenAIRE
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