Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial
| Autor: | Mona K. Chaturvedi, Arun Gupta, Aruna Chandran, Neha Bagri, Satinder Aneja, Sean Fitzwater, Jagdish Chandra, Shinjini Bhatnagar, Narendra Kumar Bagri, Rakesh Lodha, Bimbadhar Rath, Mathuram Santosham, Nitya Wadhwa, Jitender Sodhi, Udaypal S Kainth, Savita Saini, Sushil K. Kabra, Manisha Jana, Robert E. Black |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Placebo Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Interquartile range 030225 pediatrics Internal medicine medicine Adjuvant therapy Humans 030212 general & internal medicine Lung Proportional Hazards Models business.industry Proportional hazards model Absolute risk reduction Infant Pneumonia medicine.disease Survival Analysis Confidence interval Surgery Zinc Treatment Outcome Infectious Diseases Dietary Supplements Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Journal of Tropical Pediatrics. 64:110-117 |
| ISSN: | 1465-3664 0142-6338 |
| DOI: | 10.1093/tropej/fmx036 |
| Popis: | Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia. |
| Databáze: | OpenAIRE |
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