Role of anti-Müllerian hormone and testosterone in follicular growth: a cross-sectional study

Autor: Lei Feng, Min Jin, Song-Qing Yang, Qiu-Ping Yao, Chang-Chang Huang, Jin-Peng Rao, Jian Chen, Jin-Ming Shen, Li-Quan Wang, Ping-Ping Lv, Chun Feng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
Anti-Mullerian Hormone
medicine.medical_specialty
endocrine system
China
endocrine system diseases
Anti-Müllerian hormone (AMH)
Follicle-stimulating hormone (FSH)
Polycystic ovarian syndrome (PCOS)
Endocrinology
Diabetes and Metabolism
Controlled ovarian hyperstimulation
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Sex hormone-binding globulin
Ovarian Follicle
Internal medicine
Follicular phase
medicine
Humans
Testosterone
Ovarian reserve
Ovarian Reserve
Retrospective Studies
030219 obstetrics & reproductive medicine
lcsh:RC648-665
biology
business.industry
Luteinizing hormone (LH)
Anti-Müllerian hormone
General Medicine
female genital diseases and pregnancy complications
030104 developmental biology
Endocrinology
Cross-Sectional Studies
biology.protein
Diminished ovarian reserve (DOR)
Female
business
Luteinizing hormone
hormones
hormone substitutes
and hormone antagonists
Hormone
Research Article
Polycystic Ovary Syndrome
Zdroj: BMC Endocrine Disorders
BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-10 (2020)
ISSN: 1472-6823
Popis: Background Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian reserve (DOR) and polycystic ovarian syndrome (PCOS) as two extremes of ovarian reserve (deficient and excessive respectively) to investigate the role of AMH and sex hormones in follicular growth. Methods A retrospective cross-sectional survey was performed. The patients assessed AMH and basal sex hormones in the Second Hospital of Zhejiang University from April 2016 to March 2019 were involved in this study. Serum AMH and sex hormone concentrations were tested with electrochemiluminescence method. Stepwise linear regression and binary logistic regression was used to determine the predictors of AMH level and to explore the involved factors determining DOR and PCOS. Results In the present study, we found that age and follicle-stimulating hormone (FSH) were main negative correlation factors, and luteinizing hormone (LH) and testosterone (T) were main positive factors of AMH. In DOR group, age, FSH and estradiol (E2) increased and T decreased, while in PCOS group, LH and T increased. Binary logistic regression found that age, weight, FSH, E2, and T were the significant factors which independently predicted the likelihood of DOR, and that age, body mass index (BMI), AMH, LH, and T predicted the likelihood of PCOS. Conclusions Our study demonstrated that age, FSH, and T were factors that most closely correlated with AMH level, and T was involved in both DOR and PCOS. Since DOR and PCOS are manifested with insufficient AMH and excessive AMH respectively, it is suggested that total testosterone correlated with AMH closely and plays an important role in follicular growth. More attention should be given to testosterone level during controlled ovarian hyperstimulation (COH) process.
Databáze: OpenAIRE
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