The food supplement coenzyme Q10 and suppression of antitubercular drug-induced hepatic injury in rats: the role of antioxidant defence system, anti-inflammatory cytokine IL-10
| Autor: | Udhaya Lavinya Baskaran, Evan Prince Sabina |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
Ubiquinone medicine.drug_class Health Toxicology and Mutagenesis medicine.medical_treatment Anti-Inflammatory Agents Antitubercular Agents Pharmacology Toxicology Antioxidants Anti-inflammatory Lipid peroxidation chemistry.chemical_compound Oral administration Isoniazid Animals Medicine heterocyclic compounds Rats Wistar Coenzyme Q10 business.industry Albumin Vitamins Cell Biology Glutathione biochemical phenomena metabolism and nutrition bacterial infections and mycoses Interleukin-10 Rats Liver chemistry Dietary Supplements Female Liver function Chemical and Drug Induced Liver Injury Rifampin business Silymarin |
| Zdroj: | Cell Biology and Toxicology. 31:211-219 |
| ISSN: | 1573-6822 0742-2091 |
| Popis: | Isoniazid (INH) and rifampicin (RIF), the most common anti-tubercular therapy, causes hepatotoxicity through a multi-step mechanism in certain individuals. The present study was an attempt to evaluate the hepatoprotective effect of coenzyme Q10 against INH + RIF-induced hepatotoxicity in Wistar albino rats. Hepatotoxicity was induced by the oral administration of INH + RIF (50 mg/kg b.w. each/day) in normal saline water for 28 days. The hepatoprotective effect of coenzyme Q10 (10 mg/kg b.w./day) was compared with that of the standard drug silymarin (25 mg/kg b.w./day). Animals were sacrificed at the end of the study period, and blood and liver were collected for biochemical, immunological and histological analyses. Evaluation of biochemical parameters showed that coenzyme Q10 treatment caused significant (P |
| Databáze: | OpenAIRE |
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