Efficacy of levofloxacin versus cefuroxime in treating acute exacerbations of chronic obstructive pulmonary disease
| Autor: | Ho Il Yoon, Geun Min Park, Jae-Ho Lee, Chul Gyu Yoo, Choon Taek Lee, Jae-Joon Yim, Sangmin Lee, Deog Kyeom Kim, Young Whan Kim, Hee Soon Chung, Changhoon Lee, Jae Yeol Kim, Sung Koo Han |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Acute exacerbation of chronic obstructive pulmonary disease Ofloxacin medicine.drug_class Antibiotics Pulmonary disease Microbial Sensitivity Tests International Journal of Chronic Obstructive Pulmonary Disease law.invention chronic obstructive pulmonary disease Pulmonary Disease Chronic Obstructive Randomized controlled trial law Levofloxacin Internal medicine medicine Humans In patient Intensive care medicine acute exacerbation Aged Original Research COPD Cefuroxime levofloxacin Bacteria Dose-Response Relationship Drug business.industry Patient Acuity General Medicine Middle Aged medicine.disease Anti-Bacterial Agents Treatment Outcome Female Drug Monitoring business medicine.drug |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| Popis: | Ho Il Yoon,1 Chang-Hoon Lee,2 Deog Kyeom Kim,3 Geun Min Park,4 Sang-Min Lee,2 Jae-Joon Yim,2 Jae-Yeol Kim,5 Jae Ho Lee,1 Choon-Taek Lee,1 Hee Soon Chung,3 Young Whan Kim,2 Sung Koo Han,2 Chul-Gyu Yoo2 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea; 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; 3Division of Pulmonology, Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, South Korea; 4Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea; 5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea Background: Antibiotic treatment is one of the major pharmacologic treatments for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the choice of antibiotic depends on the local resistance pattern. A multicenter, randomized, controlled trial was done in patients with AECOPD to compare the efficacy of levofloxacin with that of cefuroxime axetil. Methods: Patients with AECOPD and without radiographic evidence of pneumonia were enrolled and randomized to either levofloxacin 500 mg daily or cefuroxime 250 mg twice daily in the mild-moderate exacerbation group, or 500 mg twice daily in the severe exacerbation group, for seven days. Clinical efficacy and microbiologic response were evaluated 5–7 days after the last dose. Results: Treatment was clinically successful in 90.4% of patients in the levofloxacin group, and in 90.6% of patients in the cefuroxime group (95% confidence interval -9.40 to 10.91), within a noninferiority margin of 10%. The microbiologic response appeared to be higher in the levofloxacin group, but the difference was not statistically significant. The safety profile was similar in both groups. Conclusion: Levofloxacin is not inferior to cefuroxime with regard to clinical efficacy in treating AECOPD. Keywords: chronic obstructive pulmonary disease, acute exacerbation, levofloxacin, cefuroxime |
| Databáze: | OpenAIRE |
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