Distribution of hepatitis C virus genotypes and subtypes in Croatia: 2008-2015
| Autor: | Sendi Kuret, Ivana Baća Vrakela, Ivan Kurelac, Adriana Vince, Jasna Bingulac-Popović, Snježana Židovec Lepej, Manuela Miletić, Sanda Sardelić |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Genotype Croatia Hepatitis C virus HCV genotypes Hepacivirus medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine In patient Genotyping Retrospective Studies Croatian Molecular epidemiology business.industry Public Health Environmental and Occupational Health General Medicine Hepatitis C Chronic hepatitis C virus genotypes subtypes Croatia Subtyping language.human_language 030104 developmental biology language Female 030211 gastroenterology & hepatology business |
| Zdroj: | Central European Journal of Public Health. 26:159-163 |
| ISSN: | 1803-1048 1210-7778 |
| Popis: | Objective: Hepatitis C virus (HCV) genotyping is an important part of pre-treatment diagnostic algorithms as it guides the choice of therapeutic regimens. The aim of this study was to analyse the distribution of HCV genotypes in patients with chronic hepatitis C from Croatia in the period 2008-2015. Methods: The study enrolled 3, 655 anti-HCV positive patients with available results of HCV genotyping from the three largest national HCV genotyping laboratories. Results: The majority of HCV-infected individuals enrolled in the study were male (70.7%). Analysis of age distribution in a subset of 2, 164 individuals showed a mean age of 40.9 years (SD 11.77 years). Croatian patients were mostly infected with HCV genotype 1 (56.6%), followed by genotype 3 (37.3%), genotype 4 (4.2%) and genotype 2 (1.8%). Genotype 1 subtyping in a subset of 1, 488 patients showed 54% (803/1, 488) of 1b infections and 46% (685/1, 488) of 1a infections. Percentages of genotype 1 were the highest in Central/Northwestern and Eastern Croatia and the lowest in the Central/Southern Adriatic Region. Genotype 3 was most frequently found in the Central/Southern Adriatic Region (49.1%) but represented only 17.5% of infections in Eastern Croatia (p < 0.001). Conclusions: The results of this nine-year retrospective analysis on the distribution of HCV genotypes and subtypes in 3, 655 HCV-infected individuals from Croatia showed that the majority of infections can be attributed to genotypes 1 and 3 with absence of major changes in the molecular epidemiology of the two most frequent HCV genotypes infection in Croatia in the past 20 years. |
| Databáze: | OpenAIRE |
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