A SARS-CoV-2 -human metalloproteome interaction map

Autor: Geir Bjørklund, Athanasia K. Georgiopoulou, Spyros P. Perlepes, Massimiliano Francesco Peana, Christos T. Chasapis
Rok vydání: 2021
Předmět:
viruses
PD
Parkinson's Diseases
VPS11
vacuolar protein sorting-associated protein 11
HNSCC
head and neck squamous cell carcinoma
medicine.disease_cause
01 natural sciences
Biochemistry
CSNK2B
casein kinase II subunit beta
Pandemic
HT
hypertension
Coronavirus
Genetics
Chemistry
virus diseases
Metal homeostasis
COVID-19
corona virus disease 2019
CPS1
carbamoyl-phosphate synthase 1
SIRT5
sirtuin-5
AMD
age macular degeneration
Proteome
Host-Pathogen Interactions
Coronavirus disease 2019 (COVID-19)
PPI
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
CNS
central nervous system
010402 general chemistry
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Article
Virus
PPI
protein-protein interaction
Inorganic Chemistry
Viral Proteins
Metalloproteins
DNMT1
DNA methyltransferase 1
medicine
Humans
Cb5
cytochrome b5
AD
Alzheimer's Disease
Human proteins
010405 organic chemistry
SARS-CoV-2
SARS-CoV-2 orf8
COVID-19
KRCC
kidney renal clear cell carcinoma
Metalloproteome
0104 chemical sciences
ZNF318
zinc finger protein 318
Carrier protein
Nervous System Diseases
Carrier Proteins
ITGB1
integrin beta-1
Zdroj: Journal of Inorganic Biochemistry
ISSN: 1873-3344
Popis: The recent pandemic caused by the novel coronavirus resulted in the greatest global health crisis since the Spanish flu pandemic of 1918. There is limited knowledge of whether SARS-CoV-2 is physically associated with human metalloproteins. Recently, high-confidence, experimentally supported protein-protein interactions between SARS-CoV-2 and human proteins were reported. In this work, 58 metalloproteins among these human targets have been identified by a structure-based approach. This study reveals that most human metalloproteins interact with the recently discovered SARS-CoV-2 orf8 protein, whose antibodies are one of the principal markers of SARS-CoV-2 infections. Furthermore, this work provides sufficient evidence to conclude that Zn2+ plays an important role in the interplay between the novel coronavirus and humans. First, the content of Zn-binding proteins in the involved human metalloproteome is significantly higher than that of the other metal ions. Second, a molecular linkage between the identified human Zn-binding proteome with underlying medical conditions that might increase the risk of severe illness from the SARS-CoV-2 virus has been found. Likely perturbations of host cellular metal homeostasis by SARS-CoV-2 infection are highlighted.
Graphical abstract Unlabelled Image
Databáze: OpenAIRE
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