dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster
| Autor: | Maria Pia Bozzetti, Simona D'Attis, Antonietta Puricella, Valeria Specchia |
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| Přispěvatelé: | Specchia, Valeria, D'Attis, Simona, Puricella, Antonietta, Bozzetti, Maria Giuseppina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system Small RNA FMRP/dFmr1 Piwi-interacting RNA Review Catalysis Evolution Molecular Inorganic Chemistry Fragile X Mental Retardation Protein 03 medical and health sciences microRNA medicine Animals Drosophila Proteins Humans RNA Small Interfering Physical and Theoretical Chemistry Gonads Molecular Biology Gene Drosophila Spectroscopy Genetics biology piRNA pathway urogenital system Macroorchidism Organic Chemistry Epistasis Genetic General Medicine dFmr1 interactors medicine.disease biology.organism_classification Phenotype Computer Science Applications Drosophila melanogaster 030104 developmental biology Gene Expression Regulation RNA Small Untranslated fragile-X syndrome RNA Interference crystal-Stellate system Carrier Proteins Protein Binding |
| Zdroj: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms18051066 |
| Popis: | Fragile-X syndrome is the most common form of inherited mental retardation accompanied by other phenotypes, including macroorchidism. The disorder originates with mutations in the Fmr1 gene coding for the FMRP protein, which, with its paralogs FXR1 and FXR2, constitute a well-conserved family of RNA-binding proteins. Drosophila melanogaster is a good model for the syndrome because it has a unique fragile X-related gene: dFmr1. Recently, in addition to its confirmed role in the miRNA pathway, a function for dFmr1 in the piRNA pathway, operating in Drosophila gonads, has been established. In this review we report a summary of the piRNA pathways occurring in gonads with a special emphasis on the relationship between the piRNA genes and the crystal-Stellate system; we also analyze the roles of dFmr1 in the Drosophila gonads, exploring their genetic and biochemical interactions to reveal some unexpected connections. |
| Databáze: | OpenAIRE |
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