Inhibition of multiplication of Mycobacterium leprae in mouse foot pads by immunization with ribosomal fraction and culture filtrate from Mycobacterium bovis BCG
| Autor: | Sohkichi Matsumoto, Masanori Matsuoka, Katsutoshi Mise, Hiroko Nomaguchi, Hideharu Yukitake, Naoya Ohara, Takeshi Yamada |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Ribosomal Proteins Ratón Bacillus Biology Ribosome Microbiology Mice Ribosomal protein Animals Mycobacterium leprae Mycobacterium bovis General Veterinary General Immunology and Microbiology Foot Public Health Environmental and Occupational Health Ribosomal RNA biology.organism_classification Mice Inbred C57BL Infectious Diseases RNA Ribosomal Molecular Medicine Immunization Bacteria Filtration |
| Zdroj: | Vaccine. 15(11) |
| ISSN: | 0264-410X |
| Popis: | Immunization of mice with the ribosomal fraction from ruptured Mycobacterium bovis Bacillus Calmette-Guerin (BCG) and the culture filtrate reduced remarkably the multiplication of Mycobacterium leprae in the foot pads of mice. This is the first reported case of the protective activity against M. leprae multiplication in mice of the BCG ribosomal fraction and culture filtrate. The inhibition was more evident with the culture filtrate than with the ribosomal fraction. When the ribosomal proteins separated from ribosomal RNA were injected into mice, only slight inhibition was observed. Ribosomal RNA alone did not inhibit at all, in contrast to the conclusion reported by Youmans and Youmans. |
| Databáze: | OpenAIRE |
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