A Case of Primary Myelofibrosis With Transformation to Leukemia Cutis
Autor: | Aayushma Regmi, Kumaran Mudaliar, Kamran M. Mirza, Jodi Speiser, Reeba Omman, Milind Velankar, Jasmine Saleh |
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Rok vydání: | 2021 |
Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms Dermatology Pathology and Forensic Medicine Fatal Outcome Leukemic Infiltration hemic and lymphatic diseases Biopsy medicine Humans Myelofibrosis CD20 biology medicine.diagnostic_test CD117 business.industry Myeloid leukemia Leukemia cutis General Medicine Middle Aged medicine.disease Leukemia Myeloid Acute medicine.anatomical_structure Primary Myelofibrosis biology.protein Bone marrow Differential diagnosis medicine.symptom business |
Zdroj: | The American Journal of dermatopathology. 44(1) |
ISSN: | 1533-0311 |
Popis: | We report an extraordinary case of primary myelofibrosis with transformation to leukemia cutis. A 64-year-old Caucasian man with a history of JAK2-positive primary myelofibrosis presented with erythematous papulonodules on his right lower extremity. A punch biopsy revealed a normal epidermis with an underlying diffuse dermal infiltrate composed of medium-to-large-sized myeloid cells and leukocytes. Neoplastic cells were immunoreactive for LCA, CD34, CD61, CD117, and CD68 and negative for lysozyme, CD20, CD3, myeloperoxidase, and TdT. These findings were consistent with a diagnosis of leukemia cutis. A concurrent bone marrow biopsy demonstrated a markedly fibrotic, hypercellular marrow without a significant increase in blasts. With no morphologic evidence of bone marrow involvement by acute myeloid leukemia, our case suggests that the patient's primary myelofibrosis transformed to leukemia cutis. Our patient died 2 months after the onset of his skin nodules. Our case demonstrates that leukemia cutis should be included in the differential diagnosis for cutaneous nodular lesions in patients with a history of an advanced-stage hematological malignancy. |
Databáze: | OpenAIRE |
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