Age-related changes in very low density lipoprotein metabolism in normal rats
| Autor: | Carl E. Mondon, Gerald M. Reaven, Ted A. Tobey |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Very low-density lipoprotein Aging Endocrinology Diabetes and Metabolism Fatty Acids Nonesterified In Vitro Techniques Lipoproteins VLDL Liver weight Endocrinology Internal medicine Age related Perfused liver medicine Animals Secretion Triglycerides Chemistry nutritional and metabolic diseases Metabolism Organ Size Rats Perfusion Kinetics Liver Rat liver lipids (amino acids peptides and proteins) Plasma free fatty acid |
| Zdroj: | Metabolism: clinical and experimental. 30(6) |
| ISSN: | 0026-0495 |
| Popis: | Plasma triglyceride (TG) concentrations rise with age, and we have carried out studies of very low density lipoprotein (VLDL) kinetics in the rat in an effort to define the cause of this phenomenon. Efficiency of VLDL-TG secretion by perfused rat liver decreases as rats age from 112–12 mo. However, this is compensated for by an increase in liver weight, and VLDL-TG secretion per perfused liver does not change with age. In contrast, total VLDL-TG secretion by the intact rat increases significantly as rats grow from 112–12 mo of age, and this increase is proportionate to the age-related increase in liver weight. The ability of the older rat to maintain VLDL-TG secretion proportionate to liver weight is most likely due to the concomitant rise in plasma free fatty acid concentration that occurs with age. However, the efficiency with which VLDL-TG is removed from plasma is not maintained as rats age. Consequently, the age-related rise in plasma TG concentration is due to an increase in VLDL-TG secretion proportionate to secretory mass, accompanied by a relative decline in efficiency of VLDL-TG removal from plasma. |
| Databáze: | OpenAIRE |
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