The possible involvement of brain microtubules in memory fixation
| Autor: | Carole Birks, David Carden, J Cronly-Dillon |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Physiology
education Color Aquatic Science Microtubules Synaptic Transmission Injections Discrimination Learning chemistry.chemical_compound Microtubule Memory Goldfish Avoidance Learning Medicine Colchicine Animals Humans Molecular Biology Ecology Evolution Behavior and Systematics business.industry Retrograde amnesia Brain medicine.disease Regression Psychology chemistry Insect Science Depression Chemical Protein Biosynthesis Fixation (visual) Synapses Fish Animal Science and Zoology business Neuroscience |
| Zdroj: | The Journal of experimental biology. 61(2) |
| ISSN: | 0022-0949 |
| Popis: | Goldfish were trained to discriminate between two coloured lights. When colchicine was administered intracranially immediately after training it produced complete retrograde amnesia 2 days later, but the fish displayed considerable retention if instead the injection was given 1.25 h after training. If colchicine was administered 1.25 h before training the fish were able to learn as readily as control fish but then showed retrograde amnesia when tested 2 days later. It is suggested that colchicine may affect memory fixation by interfering with the fast transport of material needed to bring about a structural modification at certain synapses. |
| Databáze: | OpenAIRE |
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