From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?
| Autor: | Giulia Puliani, Andrea Lania, Fabio Lo Calzo, Valentina Guarnotta, Giuseppe Fanciulli, Alessandra Dicitore, Carmen Rainone, Annamaria Colao, Genoveffa Pizza, Manila Rubino, Giovanni Vitale, Severo Campione, Francesco Ferraù, Maria Chiara Zatelli, Mary Anna Venneri, Emilia Sbardella, Diego Ferone, Marco Gallo, Riccardo Pofi, Roberta Modica, Luigi Barrea, Erika Grossrubatscher, Federica Grillo, Antongiulio Faggiano, Franz Sesti, Rosa Maria Ruggieri, Barbara Altieri, Erika Messina, Luca Pes, P. Razzore, Nike, Andrea M. Isidori, Sergio Di Molfetta, Pasquale Malandrino, Andrea Lenzi, Manuela Albertelli, Tiziana Feola, Laura Rizza, Giovanna Muscogiuri, Federica de Cicco, Filomena Bottiglieri, Elia Guadagno, Elisa Giannetta |
|---|---|
| Přispěvatelé: | Vitale G, Dicitore A, Barrea L, Sbardella E, Razzore P, Campione S, Faggiano A, Colao A, NIKE, Albertelli M, Altieri B, Bottiglieri F, De Cicco F, Di Molfetta S, Fanciulli G, Feola T, Ferone D, Ferraù F, Gallo M, Giannetta E, Grillo F, Grossrubatscher E, Guadagno E, Guarnotta V, Isidori AM, Lania A, Lenzi A, Calzo FL, Malandrino P, Messina E, Modica R, Muscogiuri G, Pes L, Pizza G, Pofi R, Puliani G, Rainone C, Rizza L, Rubino M, Ruggieri RM, Sesti F, Venneri MA, Zatelli MC., Vitale, G., Dicitore, A., Barrea, L., Sbardella, E., Razzore, P., Campione, S., Faggiano, A., Colao, A., Albertelli, M., Altieri, B., Bottiglieri, F., De Cicco, F., Di Molfetta, S., Fanciulli, G., Feola, T., Ferone, D., Ferrau, F., Gallo, M., Giannetta, E., Grillo, F., Grossrubatscher, E., Guadagno, E., Guarnotta, V., Isidori, A. M., Lania, A., Lenzi, A., Calzo, F. L., Malandrino, P., Messina, E., Modica, R., Muscogiuri, G., Pes, L., Pizza, G., Pofi, R., Puliani, G., Rainone, C., Rizza, L., Rubino, M., Ruggieri, R. M., Sesti, F., Venneri, M. A., Zatelli, M. C. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Tumor microenvironment Biology Gut flora Neuroendocrine tumors medicine.disease_cause digestive system Article 03 medical and health sciences 0302 clinical medicine Endocrinology Immune system Neuroendocrine tumor Gastro medicine Humans Cytokine 030304 developmental biology Gastrointestinal Neoplasms Inflammation 0303 health sciences Microbiota digestive oral and skin physiology medicine.disease biology.organism_classification Cytokines Gastrointestinal Microbiome 030220 oncology & carcinogenesis Immunology Dysbiosis Carcinogenesis Drug metabolism |
| Zdroj: | Reviews in Endocrine & Metabolic Disorders |
| Popis: | Gut microbiota is represented by different microorganisms that colonize the intestinal tract, mostly the large intestine, such as bacteria, fungi, archaea and viruses. The gut microbial balance has a key role in several functions. It modulates the host’s metabolism, maintains the gut barrier integrity, participates in the xenobiotics and drug metabolism, and acts as protection against gastro-intestinal pathogens through the host’s immune system modulation. The impaired gut microbiota, called dysbiosis, may be the result of an imbalance in this equilibrium and is linked with different diseases, including cancer. While most of the studies have focused on the association between microbiota and gastrointestinal adenocarcinomas, very little is known about gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs). In this review, we provide an overview concerning the complex interplay between gut microbiota and GEP NENs, focusing on the potential role in tumorigenesis and progression in these tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|