Modeling the Kinetic Behavior of Reactive Oxygen Species with Cerium Dioxide Nanoparticles
| Autor: | Gwendolyn Doherty, Zachary Burns, Kara L. Maki, Nathan Bush, Michael Cromer, Kenneth J. Reed, Thomas Foley, Matthew Milone |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:QR1-502
chemistry.chemical_element 02 engineering and technology Photochemistry 01 natural sciences Biochemistry Article lcsh:Microbiology Catalysis dismutation Superoxide dismutase chemistry.chemical_compound steady-state kinetics Humans Hydrogen peroxide Molecular Biology chemistry.chemical_classification reactive oxygen species Reactive oxygen species biology nanotechnology 010405 organic chemistry Superoxide catalase time-dependent kinetics ROS system of differential equations Cerium 021001 nanoscience & nanotechnology cerium dioxide 0104 chemical sciences chemistry Models Chemical Catalase kinetics biology.protein Hydroxide Nanoparticles 0210 nano-technology |
| Zdroj: | Biomolecules, Vol 9, Iss 9, p 447 (2019) Biomolecules Volume 9 Issue 9 |
| Popis: | The world of medicinal therapies has been historically, and remains to be, dominated by the use of elegant organic molecular structures. Now, a novel medical treatment is emerging based on CeO2 nano-crystals that are discrete clusters of a few hundred atoms. This development is generating a great deal of exciting and promising research activity, as evidenced by this Special Issue of Biomolecules. In this paper, we provide both a steady-state and time-dependent mathematical description of a sequence of reactions: superoxide generation, superoxide dismutase, and hydrogen peroxide catalase and ceria regeneration. This sequence describes the reactive oxygen species (ROS) superoxide, O2&ndash molecular oxygen, O2, hydroxide ion OH&ndash and hydrogen peroxide, H2O2, interacting with the Ce3+, and Ce4+ surface cations of nanoparticle ceria, CeO2. Particular emphasis is placed on the predicted time-dependent role of the Ce3+/Ce4+ ratio within the crystal. The net reaction is succinctly described as: H2O2 + 2O2&ndash + 2H+ &rarr 2H2O + 2O2. The chemical equations and mathematical treatment appears to align well with several critical in vivo observations such as direct and specific superoxide dismutase (SOD), ROS control, catalytic regeneration, ceria self-regulation and self-limiting behavior. However, in contrast to experimental observations, the model predicts that the 4+ ceric ion state is the key SOD agent. Future work is suggested based on these calculations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |