Forensic Genetics and Genotyping
| Autor: | Danijela Todorović, Radica Zivkovic-Zaric, Milos Todorovic, Zivana Slovic, Katarina Vitošević |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Genetics forensic genetics databases business.industry Population genetics General Medicine Forensic science 03 medical and health sciences Variable number tandem repeat 030104 developmental biology 0302 clinical medicine genotyping Genetic marker genetic markers SNP Microsatellite Medicine Identification (biology) 030216 legal & forensic medicine business Genotyping |
| Zdroj: | Serbian Journal of Experimental and Clinical Research, Vol 20, Iss 2, Pp 75-86 (2019) |
| ISSN: | 1820-8665 |
| Popis: | Forensic genetics represents a combination of molecular and population genetics. Personal identification and kinship analysis (e.g. paternity testing) are the two main subjects of forensic DNA analysis. Biological specimens from which DNA is isolated are blood, semen, saliva, tissues, bones, teeth, hairs. Genotyping has become a basis in the characterization of forensic biological evidence. It is performed using a variety of genetic markers, which are divided into two large groups: bi-allelic (single-nucleotide polymorphisms, SNP) and multi-allelic polymorphisms (variable number of tandem repeats, VNTR and short tandem repeats, STR). This review describes the purpose of genetic markers in forensic investigation and their limitations. The STR loci are currently the most informative genetic markers for identity testing, but in cases without a suspect SNP can predict offender’s ancestry and phenotype traits such as skin, eyes and hair color. Nowadays, many countries worldwide have established forensic DNA databases based on autosomal short tandem repeats and other markers. In order for DNA profile database to be useful at a national or international level, it is essential to standardize genetic markers used in laboratories. |
| Databáze: | OpenAIRE |
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