The genomic heritage of lymph node metastases: implications for clinical management of patients with breast cancer
| Autor: | Craig D. Shriver, Jeffrey A. Hooke, Rachel E. Ellsworth, Heather L. Patney, Rick Jordan, Darrell L. Ellsworth, T. E. Becker, Brenda Deyarmin |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
CA15-3 Adult medicine.medical_specialty Axillary lymph nodes Breast Neoplasms Allelic Imbalance Metastasis Breast cancer Internal medicine medicine Humans Lymph node Aged Aged 80 and over business.industry Cancer Middle Aged medicine.disease Primary tumor Metastatic breast cancer medicine.anatomical_structure Lymphatic Metastasis Axilla Surgery Female Lymph Nodes business |
| Zdroj: | Annals of surgical oncology. 15(4) |
| ISSN: | 1534-4681 |
| Popis: | Metastatic breast cancer is an aggressive disease associated with recurrence and decreased survival. To improve outcomes and develop more effective treatment strategies for patients with breast cancer, it is important to understand the molecular mechanisms underlying metastasis. We used allelic imbalance (AI) to determine the molecular heritage of primary breast tumors and corresponding metastases to the axillary lymph nodes. Paraffin-embedded samples from primary breast tumors and matched metastases (n = 146) were collected from 26 patients with node-positive breast cancer involving multiple axillary nodes. Hierarchical clustering was used to assess overall differences in the patterns of AI, and phylogenetic analysis inferred the molecular heritage of axillary lymph node metastases. Overall frequencies of AI were significantly higher (P |
| Databáze: | OpenAIRE |
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