| Popis: |
Summary 1. Lesions resembling human cases of pseudomembranous enterocolitis have been produced in dogs by the intra-aortic injection of (a) incompatible blood, (b) thrombin, (c) bacterial endotoxin. 2. All three of these agents caused (a) intravascular coagulation, (b) irreversible shock, (c) alteration in the hemostatic mechanism. 3. The alteration in the hemostatic mechanism was characterized by: (a) Fall in blood levels (due to using up) of blood clotting elements including (1) fibrinogen, (2) platelets, (3) prothrombin; (b) Activation in the blood stream of (1) heparin and other antithrombins, (2) fibrinolysin (this is probably a protective mechanism). 3. Heparin will prevent these changes to a large extent. 4. There is evidence that pathogenic staphylococci produce a substance which causes intravascular coagulation in those animals which are susceptible to the bacterial method of producing pseudomembranous enteritis. |
