Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension
| Autor: | Serpil C. Erzurum, Christina Rigelsky, Kylie M. Drake, Suzy A.A. Comhair, Sirena L. Meade, Micheala A. Aldred, Lauren N. McNelly, Chiara Federici |
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| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pathology DNA damage Hypertension Pulmonary Cell Critical Care and Intensive Care Medicine Peripheral blood mononuclear cell Internal medicine medicine.artery medicine Genetic predisposition Humans Chromosome Aberrations chemistry.chemical_classification Reactive oxygen species Lung business.industry respiratory system BMPR2 medicine.anatomical_structure Endocrinology chemistry Pulmonary artery Original Article business DNA Damage |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 192:219-228 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.201411-2128oc |
| Popis: | Rationale: Pulmonary arterial hypertension (PAH) is a serious lung condition characterized by vascular remodeling in the precapillary pulmonary arterioles. We and others have demonstrated chromosomal abnormalities and increased DNA damage in PAH lung vascular cells, but their timing and role in disease pathogenesis is unknown.Objectives: We hypothesized that if DNA damage predates PAH, it might be an intrinsic cell property that is present outside the diseased lung.Methods: We measured DNA damage, mutagen sensitivity, and reactive oxygen species (ROS) in lung and blood cells from patients with Group 1 PAH, their relatives, and unrelated control subjects.Measurements and Main Results: Baseline DNA damage was significantly elevated in PAH, both in pulmonary artery endothelial cells (P |
| Databáze: | OpenAIRE |
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