| Autor: |
Angelini, L., ANGELO RAVELLI, Caporali, R., Rumi, V., Nardocci, N., Martini, A. |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| Popis: |
Background. The presence of circulating antiphospholipid antibodies (aPLs) is frequently associated with thromboembolic phenomena. Objective. To investigate the prevalence of aPLs, detected as lupus anticoagulant (LA) or anticardiolipin antibody (aCL), in a group of unselected children with idiopathic cerebral ischemia. Design. Prospective, case series. Setting. A pediatric neurology department. Patients. Thirteen children with cerebral ischemia (eight with stroke, three with transient ischemic attacks, and two with ocular ischemia). Age-matched apparently healthy children served as controls. Measurements. LA and aCL determination was performed within 3 days after the occurrence of the ischemic event and was repeated after 3 to 6 months. To be defined as aPL-positive, patients had to have either a positive LA test or positive IgG and/or IgM aCL at moderate/high level in both determinations. Main results. Ten (76%) of the 13 patients were positive for either LA or aCL. No differences were found between aPL-positive and aPL-negative patients with respect to clinical manifestations or radiological features. Six (46%) of the 13 patients had a history of multiple ischemic events. Conclusions. Our results show a very high prevalence of aPLs in children with idiopathic cerebral ischemia. Because the presence of these antibodies has relevant therapeutic implications, their determination in children with cerebral ischemia is recommended. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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