Minimally invasive injectable lumbar interbody fusion with mineralized collagen-modified PMMA bone cement: A new animal model
| Autor: | Huiwang Wang, Chun-Fu Wu, Shaofeng Wang, Zhanyong Wu, Xiangping Peng, Jianjun Kong, Jian-Qing Ma, Chaohui Zhao, Fuzhai Cui, Zhanfeng Song, Zhiye Qiu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Biotechnology
Biomedical Engineering Biophysics Bioengineering Biocompatible Materials Fibrous capsule macromolecular substances Biomaterials 03 medical and health sciences 0302 clinical medicine Animal model Lumbar interbody fusion Pedicle Screws lcsh:TP248.13-248.65 Medicine Animals Polymethyl Methacrylate Pedicle screw fixation Bone growth Titanium 030222 orthopedics Lumbar Vertebrae business.industry Goats technology industry and agriculture Bone Cements Biomaterial General Medicine X-Ray Microtomography Bone cement equipment and supplies Spiral computed tomography body regions Spinal Fusion Models Animal Collagen business Nuclear medicine Tomography Spiral Computed 030217 neurology & neurosurgery |
| Zdroj: | Journal of Applied Biomaterials & Functional Materials, Vol 18 (2020) |
| ISSN: | 2280-8000 |
| Popis: | This study was to develop a feasible and safe animal model for minimally invasive injectable lumbar interbody fusion using a novel biomaterial, mineralized collagen-polymethylmethacrylate bone cement (MC-PMMA), with unilateral pedicle screw fixation in an in vivo goat model. Eight goats ( Capra aegagrus hircus) were divided into three groups: MC-PMMA, unmodified commercial-polymethylmethacrylate bone cement (UC-PMMA), and a control group (titanium cage filled with autogenous bone, TC-AB). Each group of goats was treated with minimally invasive lumbar interbody fusion at the L3/L4 and L5/L6 disc spaces (injected for MC-PMMA and UC-PMMA, implanted for TC-AB). The pedicle screws were inserted at the L3, L4, L5, and L6 vertebrae, respectively, and fixed on the left side. The characteristics of osteogenesis and bone growth were assessed at the third and the sixth month, respectively. The methods of evaluation included the survival of each animal, X-ray imaging, and 256-layer spiral computed tomography (256-CT) scanning, imaged with three-dimensional microfocus computed tomography (micro-CT), and histological analysis. The results showed that PMMA bone cement can be extruded smoothly after doping MC, the MC-PMMA integrates better with bone than the UC-PMMA, and all goats recovered after surgery without nerve damage. After 3 and 6 months, the implants were stable. New trabecular bone was observed in the TC-AB group. In the UC-PMMA group a thick fibrous capsule had formed around the implants. The MC-PMMA was observed to have perfect osteogenesis and bone ingrowth to adjacent bone surface. Minimally invasive injectable lumbar interbody fusion using MC-PMMA bone cement was shown to have profound clinical value, and the MC-PMMA showed potential application prospects. |
| Databáze: | OpenAIRE |
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