Single-channel and whole-cell currents in rat cerebellar granule cells
| Autor: | T. Jalonen, Peter Århem, S. S. Oja, Stig-Arne Johansson, I. Holopainen |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Cerebellum
Potassium Channels Potassium Action Potentials chemistry.chemical_element Membrane Potentials medicine Animals Patch clamp Molecular Biology Cells Cultured Cardiac transient outward potassium current Chemistry General Neuroscience Rats Inbred Strains Granule cell Potassium channel Calcium-activated potassium channel Rats Electrophysiology medicine.anatomical_structure Biophysics Neurology (clinical) Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 535:33-38 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(90)91820-7 |
| Popis: | The patch-clamp technique was used to study both whole-cell and single-channel currents in cultured rat cerebellar granule cells. In whole-cell recording under voltage-clamp conditions 3 types of current were found; a transient inward sodium current and a transient and a sustained outward potassium current. Single-channel currents were recorded from both inside-out and outside-out membrane patches. Three types of potassium channel were identified; two non-inactivating channels with unit conductances of 160 and 60 pS and one inactivating channel of 20 pS. No calcium currents were detected. |
| Databáze: | OpenAIRE |
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