Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking
| Autor: | Jürgen Brinkmeyer, Thomas F. Wienker, Johannes Kornhuber, Norbert Dahmen, Falk Kiefer, Amalia Diaz-Lacava, Nadine Petrovsky, Juergen Gallinat, Georg Winterer, C. von der Goltz, Tomislav Majić, Christina Dinter, Arian Mobascher, Holger Thiele, Jochen Mutschler, Michael Wagner, Gerd Gründer, Elvira Abbruzzese, Norbert Thuerauf |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Candidate gene Health (social science) Genotype media_common.quotation_subject Population Medicine (miscellaneous) Anxiety Polymorphism Single Nucleotide White People Nicotine 610 Medical sciences Medicine Gene Frequency Medizinische Fakultät Internal medicine Humans Medicine SNP Genetic Predisposition to Disease Neuropeptide Y ddc:610 Allele Promoter Regions Genetic education Alleles media_common education.field_of_study business.industry Addiction Smoking Tobacco Use Disorder Middle Aged Neuropeptide Y receptor Psychiatry and Mental health Endocrinology Case-Control Studies Female business medicine.drug |
| Zdroj: | European Addiction Research |
| DOI: | 10.11588/heidok.00017794 |
| Popis: | Background: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking. Methods: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 550 Caucasian current smokers, and 544 never-smokers were genotyped for SNP rs16147 and behaviorally characterized with the State-Trait Anxiety Inventory (STAI). Results: Subjects with TT genotype of the SNP rs16147 were significantly more frequently smokers than never-smokers (p = 0.046). In addition, TT genotype exhibited increased state anxiety scores compared to carriers of the C allele (p = 0.037). Conclusions: Our results provide evidence for an involvement of the functionally relevant SNP rs16147 in the pathophysiology of tobacco dependence. Further studies are needed to confirm our findings. |
| Databáze: | OpenAIRE |
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