Neuropsychological profile in new-onset benign epilepsy with centrotemporal spikes (BECTS): Focusing on executive functions
| Autor: | Francesco Benso, Silvia Stefanelli, Melissa Filippini, Giuseppe Gobbi, Antonella Boni, Eleonora Ardu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Standardized test Audiology Electroencephalography Neuropsychological Tests Non-rapid eye movement sleep 050105 experimental psychology Developmental psychology 03 medical and health sciences Behavioral Neuroscience Epilepsy Executive Function 0302 clinical medicine medicine Humans Learning 0501 psychology and cognitive sciences Attention Prospective Studies Prospective cohort study Child medicine.diagnostic_test business.industry 05 social sciences Neuropsychology Benign epilepsy with centrotemporal spikes Executive functions Neuropsychological profile at the onset medicine.disease Epilepsy Rolandic Memory Short-Term Neurology Reading Child Preschool Benign epilepsy Female Neurology (clinical) business Psychology 030217 neurology & neurosurgery |
| Zdroj: | Epilepsybehavior : EB. 54 |
| ISSN: | 1525-5069 |
| Popis: | Increased evidence of subnormal neuropsychological functioning in new-onset childhood epilepsy has been obtained, although results are still rare and controversial. With a prospective study, we aimed to define the very early neuropsychological profile of children with benign epilepsy with centrotemporal spikes (BECTS), including executive functions (EF) because of their key role in learning. Additionally, we enrolled drug-naïve children, with a NREM sleep frequency of discharges85% and with a Performance Intelligence Quotient equal or superior to 85, in order to exclude additional effects on the neuropsychological functioning.Fifteen school-aged children with BECTS (mean age: 8.8years, standard deviation [SD]: 2.4years) and fifteen healthy children (mean age: 9.2years, [SD]: 2.5years) were enrolled and assessed with a comprehensive neuropsychological battery. The assessment included domain-specific standardized tests of language, EF, academic skills, visuomotor and visuospatial skills, and short-term memory. A p-value0.05 was considered significant.Significant differences between patients and controls emerged with respect to 3 domains. Language was affected in color naming (p=.026), spoonerism (p=.003), and phonemic synthesis (p=.009). Executive functions appeared inadequate in the five point test with respect to the number of correct figures (p=.003) and errors (p=.008). In the domain of academic skills, significant differences between groups emerged regarding the number of mistakes in nonword writing (p=.001), nonword reading speed (p=.027), nonword reading number of mistakes (p=.019), and word reading errors (p=.023).Results showed that children with new-onset BECTS may demonstrate a range of neuropsychological dysfunctions, particularly affecting executive attention, despite a normal IQ, a low frequency of NREM sleep discharges, and the absence of drugs. These difficulties indicate a frontal dysfunction with cascading effects on language and academic skills. The inclusion of EF in the assessment battery and in the intervention since the very onset is warranted in order to avoid further and persistent academic difficulties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect