A study on the morbid histopathological changes in COVID‐19 patients with or without comorbidities using minimally invasive tissue sampling

Autor: Ayush Goel, Animesh Ray, Amitkumar Chavan, Shubham Sahni, Baidhnath K. Gupta, Shrawan K. Raut, Shubham Agarwal, Jagbir Nehra, Bharadhan Somu, Ragu Raja, null Aakansha, Chitrakshi Nagpal, Chaithra Rajanna, Anand Shahi, Anand Rajendran, Ashwin Varadrajan, Inamul Hasan, Pratheek Choppala, Megha Priyadarshi, Deepali Jain, Arulselvi Subramanian, Sudheer Arava, Geetika Singh, Prasenjit Das, Chitra Sarkar, Neeraj Nischal, Manish Soneja, Pankaj Jorwal, Anjan Trikha, Naveet Wig
Rok vydání: 2022
Předmět:
Zdroj: Journal of Medical Virology. 95
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.28384
Popis: COVID-19 causes morbid pathological changes in different organs including lungs, kidneys, liver, etc., especially in those who succumb. Though clinical outcomes in those with comorbidities are known to be different from those without - not much is known about the differences at the histopathological level.To compare the morbid histopathological changes in COVID-19 patients between those who were immunocompromised (Gr 1), malignancy (Gr 2), or had cardiometabolic conditions (hypertension, diabetes, or coronary artery disease) (Gr 3).Post-mortem tissue sampling (MITS) was done from the lungs, kidney, heart, and liver using a biopsy gun within two hours of death. Routine (HE stain) and special stains (AFB, SM, PAS) were done besides immunohistochemistry.A total of 100 patients underwent MITS and data of 92 were included (immunocompromised: 27, maligancy:18, cardiometabolic conditions:71). In lung histopathology, capillary congestion was more in those with malignancy while others like diffuse alveolar damage, microthrombi, pneumocyte hyperplasia, etc were equally distributed. In liver histopathology, architecture distortion was significantly different in immunocompromised while steatosis, portal inflammation, Kupffer cell hypertrophy, and confluent necrosis were equally distributed. There was a trend towards higher acute tubular injury in those with cardiometabolic conditions as compared to the other groups. No significant histopathological difference in heart was discerned.Certain histopathological features are markedly different in different groups (Gr 1,2 and 3) of COVID-19 patients with fatal outcomes. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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