Fine-Tuning TOM-Mitochondrial Import via Ubiquitin
| Autor: | Jean-François Trempe, Andrew N. Bayne, Mohamed A. Eldeeb, Edward A. Fon |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
biology Ubiquitin Tug of war TIM/TOM complex Cell Biology Mitochondrion Protein degradation Models Biological Cell biology Mitochondria Mitochondrial Proteins 03 medical and health sciences Protein Transport 0302 clinical medicine Proteasome Mitochondrial Membranes biology.protein Humans 030217 neurology & neurosurgery MARCH5 030304 developmental biology |
| Zdroj: | Trends in cell biology. 30(6) |
| ISSN: | 1879-3088 |
| Popis: | Given their polyvalent functions, an inherent challenge that mitochondria face is the exposure to mitochondrial import stresses, culminating in their dysfunction. Recently, mitochondrial import of several mitochondrial substrates was shown to be regulated via a 'tug of war' between USP30 and MARCH5, two ubiquitin-related enzymes located at the TOM complex. |
| Databáze: | OpenAIRE |
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