First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment
| Autor: | Matt Davies, Simon Cozens, Morris Muliaditan, Adeep Puri, Andrew Skingsley, Alison Gaudion, David Tenero, Alfonso Mendoza-Losana, John Tonkyn, Joaquin Rullas-Trincado, Alex Carlton, Stephanie Gresham, Geo Derimanov, David Barros-Aguirre |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Antitubercular Agents Administration Oral Urine Pharmacology Placebos GSK3036656 0302 clinical medicine Medicine Pharmacology (medical) Enzyme Inhibitors media_common 0303 health sciences Middle Aged Infectious Diseases Tolerability Area Under Curve 030220 oncology & carcinogenesis Female pharmacokinetics Adult Boron Compounds safety Drug Adolescent FTIH media_common.quotation_subject Cmax Clinical Therapeutics Placebo Heterocyclic Compounds 2-Ring Models Biological Young Adult 03 medical and health sciences Double-Blind Method Pharmacokinetics food effect Humans Tuberculosis clinical trial simulations Dosing tolerability Adverse effect 030304 developmental biology business.industry dose rationale Editor's Pick single dose Food dose escalation repeat dose Leucine-tRNA Ligase business EBA prediction |
| Zdroj: | Antimicrobial Agents and Chemotherapy |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | This first-time-in-human (FTIH) study evaluated the safety, tolerability, pharmacokinetics, and food effect of single and repeat oral doses of GSK3036656, a leucyl-tRNA synthetase inhibitor. In part A, GSK3036656 single doses of 5 mg (fed and fasted), 15 mg, and 25 mg and placebo were administered. In part B, repeat doses of 5 and 15 mg and placebo were administered for 14 days once daily. This first-time-in-human (FTIH) study evaluated the safety, tolerability, pharmacokinetics, and food effect of single and repeat oral doses of GSK3036656, a leucyl-tRNA synthetase inhibitor. In part A, GSK3036656 single doses of 5 mg (fed and fasted), 15 mg, and 25 mg and placebo were administered. In part B, repeat doses of 5 and 15 mg and placebo were administered for 14 days once daily. GSK3036656 showed dose-proportional increase following single-dose administration and after dosing for 14 days. The maximum concentration of drug in serum (Cmax) and area under the concentration-time curve from 0 h to the end of the dosing period (AUC0–τ) showed accumulation with repeated administration of approximately 2- to 3-fold. Pharmacokinetic parameters were not altered in the presence of food. Unchanged GSK3036656 was the only drug-related component detected in plasma and accounted for approximately 90% of drug-related material in urine. Based on total drug-related material detected in urine, the minimum absorbed doses after single (25 mg) and repeat (15 mg) dosing were 50 and 78%, respectively. Unchanged GSK3036656 represented at least 44% and 71% of the 25- and 15-mg doses, respectively. Clinical trial simulations were performed to guide dose escalation during the FTIH study and to predict the GSK3036656 dose range that produces the highest possible early bactericidal activity (EBA0–14) in the prospective phase II trial, with consideration of the predefined exposure limit. GSK3036656 was well tolerated after single and multiple doses, with no reports of serious adverse events. (This study has been registered at ClinicalTrials.gov under identifier NCT03075410.) |
| Databáze: | OpenAIRE |
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