Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes
| Autor: | Carmen Jurjo, Esther Rubinat, Juan Antonio Ezpeleta, Ramón Espinet, Alicia Traveset, Marta Hernández, Emilio Ortega, Beatriz Vazquez, Nuria Alcubierre, Didac Mauricio |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Article Subject Anemia Endocrinology Diabetes and Metabolism Ischemia 030209 endocrinology & metabolism Type 2 diabetes Hematocrit Gastroenterology lcsh:Diseases of the endocrine glands. Clinical endocrinology Severity of Illness Index Macular Edema 03 medical and health sciences Hemoglobins 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Severity of illness Medicine Humans Prospective Studies Macular edema Aged lcsh:RC648-665 Diabetic Retinopathy medicine.diagnostic_test business.industry Retinal Vessels Diabetic retinopathy Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Case-Control Studies 030221 ophthalmology & optometry Erythrocyte Count Female business Research Article |
| Zdroj: | Journal of Diabetes Research Journal of Diabetes Research, Vol 2016 (2016) Recercat. Dipósit de la Recerca de Catalunya instname Repositorio Abierto de la UdL Universitad de Lleida |
| ISSN: | 2314-6753 2314-6745 |
| Popis: | Aims. To assess the association of blood oxygen-transport capacity variables with the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema in patients with type 2 diabetes mellitus (T2DM).Methods. Cross-sectional, case-control study (N=312) with T2DM: 153 individuals with DR and 159 individuals with no DR. Participants were classified according to the severity of DR and the presence of retinal ischemia or macular oedema. Hematological variables were collected by standardized methods. Three logistic models were adjusted to ascertain the association between hematologic variables with the severity of DR and the presence of retinal ischemia or macular oedema.Results.Individuals with severe DR showed significantly lower hemoglobin, hematocrit, and erythrocyte levels compared with those with mild disease and in individuals with retinal ischemia and macular oedema compared with those without these disorders. Hemoglobin was the only factor that showed a significant inverse association with the severity of DR [beta-coefficient = −0.52,P value = 0.003] and retinal ischemia [beta-coefficient = −0.49,P value = 0.001]. Lower erythrocyte level showed a marginally significant association with macular oedema [beta-coefficient = −0.86,P value = 0.055].Conclusions.In patients with DR, low blood oxygen-transport capacity was associated with more severe DR and the presence of retinal ischemia. Low hemoglobin levels may have a key role in the development and progression of DR. |
| Databáze: | OpenAIRE |
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