Health-related quality of life in Japanese low-risk prostate cancer patients choosing active surveillance: 3-year follow-up from PRIAS-JAPAN
| Autor: | Hiroshi Sasaki, Kenichiro Shiga, Yoshiyuki Kakehi, Nobuyuki Miyatake, Akira Yokomizo, Sebastiaan Remmers, Shin Egawa, Takashige Abe, Lionne D.F. Venderbos, Iku Ninomiya, Takahiro Osawa, Hiromi Hirama, Katsuyoshi Hashine, Mikio Sugimoto, Ryuji Matsumoto, Takuma Kato, Monique J. Roobol, Koji Mitsuzuka |
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| Přispěvatelé: | Urology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Health related quality of life
medicine.medical_specialty education.field_of_study business.industry Urology Population 030232 urology & nephrology Age at diagnosis Medical information medicine.disease behavioral disciplines and activities humanities Discontinuation Clinical trial 03 medical and health sciences Prostate cancer 0302 clinical medicine SDG 3 - Good Health and Well-being 030220 oncology & carcinogenesis Internal medicine medicine Effective treatment education business |
| Zdroj: | World Journal of Urology, 39(7), 2491-2497. Springer-Verlag |
| ISSN: | 0724-4983 |
| Popis: | Purpose: To evaluate the health-related quality of life (HRQoL) of Japanese men on active surveillance (AS) in the Prostate cancer Research International Active Surveillance study in Japan (PRIAS-JAPAN). Methods: Participants were included in the PRIAS-JAPAN HRQoL study between January 2010 and March 2016. Their general HRQoL was assessed using a validated Japanese version of the Short-Form 8 Health Survey (SF-8) at enrolment and annually thereafter until discontinuation of AS. The SF-8 mental component summary (MCS) and physical component summary (PCS) of men on AS were compared with scores of the general population (norm-based score [NBS]: 50) and MCS and PCS scores for men following AS were analysed over time. We tested whether MCS and PCS scores over time explained discontinuation of AS. Results: Five hundred and twenty-five patients enrolled, and the median age at baseline was 68 years. At enrolment and after 1-, 2-, and 3-year follow-ups, the PCS and MCS scores were significantly higher than the NBS of the general Japanese population except for the median PCS at 3 years. We found that age at diagnosis and time on AS negatively affected the PCS score of men on AS, while every additional year on AS led to a 0.27 point increase in MCS scores. Neither PCS nor MCS were predictors for discontinuation of AS. Conclusion: Japanese men following an AS strategy for 3 years reported better HRQoL compared with the general population, indicating that monitoring Japanese low-risk prostate cancer patients can be an effective treatment strategy. Study registration: Clinical trial registry—UMIN (University Hospital Medical Information Network); UMIN000002874 (2009/12/11) |
| Databáze: | OpenAIRE |
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