Telomere length is associated with growth in children in rural Bangladesh
| Autor: | Salma Akther, Audrie Lin, Mahfuz Al Mamun, Patricia Kariger, Alan Hubbard, Ruchira Tabassum Naved, Syeda L Famida, Lia C. H. Fernald, Shahjahan Ali, Kausar Parvin, Stephen P. Luby, Palash Mutsuddi, Ziaur Rahman, Firdaus S. Dhabhar, John M. Colford, Leanne Unicomb, Mahbubur Rahman, Abul K. Shoab, Jue Lin, Christine P. Stewart, Jade Benjamin-Chung, Saheen Hossen, Sophia Tan, Andrew Mertens, Benjamin F. Arnold |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Rural Population Percentile global health First year of life Child Development telomere length Biology (General) Pediatric Bangladesh child General Neuroscience General Medicine Telomere Child Preschool Medicine epidemiology Female low-income Human Low income QH301-705.5 Science growth Biology Energy requirement General Biochemistry Genetics and Molecular Biology Clinical Research Humans human Preschool Nutrition disease General Immunology and Microbiology Infant Newborn Infant Telomere Homeostasis Newborn developmental origins of health Cross-Sectional Studies Epidemiology and Global Health Biochemistry and Cell Biology Research Advance Linear growth pediatric population Demography Pediatric population |
| Zdroj: | eLife eLife, Vol 10 (2021) |
| ISSN: | 2050-084X |
| DOI: | 10.7554/elife.60389 |
| Popis: | Background:Previously, we demonstrated that a water, sanitation, handwashing, and nutritional intervention improved linear growth and was unexpectedly associated with shortened childhood telomere length (TL) (Lin et al., 2017). Here, we assessed the association between TL and growth.Methods:We measured relative TL in whole blood from 713 children. We reported differences between the 10th percentile and 90th percentile of TL or change in TL distribution using generalized additive models, adjusted for potential confounders.Results:In cross-sectional analyses, long TL was associated with a higher length-for-age Z score at age 1 year (0.23 SD adjusted difference in length-for-age Z score [95% CI 0.05, 0.42; FDR-corrected p-value = 0.01]). TL was not associated with other outcomes.Conclusions:Consistent with the metabolic telomere attrition hypothesis, our previous trial findings support an adaptive role for telomere attrition, whereby active TL regulation is employed as a strategy to address ‘emergency states’ with increased energy requirements such as rapid growth during the first year of life. Although short periods of active telomere attrition may be essential to promote growth, this study suggests that a longer overall initial TL setting in the first 2 years of life could signal increased resilience against future telomere erosion events and healthy growth trajectories.Funding:Funded by the Bill and Melinda Gates Foundation.Clinical trial number:NCT01590095 |
| Databáze: | OpenAIRE |
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