| Popis: |
The rotacone is a modified rotarod found suitable for the measurement of drug-induced changes in motor coordination. On this apparatus mice are forced to walk against increasing surface speed until they drop off the cone. As the test is quick the animals are not exhausted, and there is no problem with mice taking “free rides”. Saline-treated mice showed a constant performance level in 4 immediately successive trials, whereas animals under the influence of drugs, especially chlordiazepoxide, showed an increase in performance in the 4 trials. After chlorpromazine, meprobamate and chlordiazepoxide there is a graded response with a normal distribution of scores. Pentobarbital gave a response of the all or non type. |
