Absence of a reservoir of Epstein-Barr virus (EBV) in normal tongue epithelium

Autor:	M. P. Cagle, D. G. Morrison, Hal B. Jenson, P. A. Eagan, Yasmin Ench, Patty Heard, D. R. Miller, Mary Pat Moyer, Margaret L. Gulley, D. DiMaio
Předmět:	Adult Male Herpesvirus 4 Human Cancer Research Adolescent Genes Viral Biology medicine.disease_cause Polymerase Chain Reaction Epithelium Herpesviridae Virus Pathology and Forensic Medicine Serology Tongue hemic and lymphatic diseases medicine Humans Gammaherpesvirinae Amino Acid Sequence Child Antigens Viral In Situ Hybridization Cell Nucleus Infant Middle Aged biology.organism_classification Virology Epstein–Barr virus DNA-Binding Proteins Blood medicine.anatomical_structure Epstein-Barr Virus Nuclear Antigens Otorhinolaryngology Child Preschool DNA Viral Trans-Activators biology.protein RNA Viral Periodontics Female Oral Surgery Antibody
Zdroj:	Scopus-Elsevier
Popis:	We examined human tongue epithelium and serum samples at autopsy for evidence of latent Epstein-Barr virus (FBV) infection. Although clinical serology revealed anti-HBV antibodies in most sera indicating past FBV infection, we found no Epstein-Barr nuclear antigen (EBNA-coding sequences in tongue tissue-by polymerase chain reaction (PCR). or Epstein-Barr-encoded RNA (EBERI) by in situ hybridization. Tongue epithelium does not appear to be a natural reservoir for latent by EBV in immunocompetent hosts
Databáze:	OpenAIRE
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