Total Mortality by Elevated Transferrin Saturation in Patients With Diabetes
| Autor: | Anne Tybjærg-Hansen, Henrik Ullitis Andersen, Christina Ellervik, Henrik Birgens, Merete Frandsen, Thomas Mandrup-Poulsen, Børge G. Nordestgaard |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Transferrin Saturation Measurement medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Elevated transferrin saturation Gastroenterology Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Genetic Predisposition to Disease Epidemiology/Health Services Research Original Research Aged Advanced and Specialized Nursing chemistry.chemical_classification Type 1 diabetes Transferrin saturation business.industry Hazard ratio Transferrin Middle Aged medicine.disease Diabetes Mellitus Type 1 Endocrinology chemistry Cohort Female business |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc12-2032 |
| Popis: | OBJECTIVE It is not known to what extent iron overload predicts prognosis in patients with diabetes after diagnosis or whether iron overload is a risk factor independent of the HFE genotype. We investigated total and cause-specific mortality according to increased transferrin saturation (≥50 vs. RESEARCH DESIGN AND METHODS Cohort 1 included patients with late-onset type 1 diabetes (n = 716) with a cross-sectional measurement of transferrin saturation and HFE genotype. Cohort 2 included consecutively recruited patients with any diabetes (n = 6,120), transferrin saturation measurement at referral, and HFE genotype if transferrin saturation was above 50%. RESULTS In cohort 1, the hazard ratio for total mortality was 2.3 (95% CI 1.3–3.9; P = 0.002) and for cause-specific mortality by neoplasms was 5.8 (2.4–14; P = 0.00007) in patients with transferrin saturation ≥50 vs. CONCLUSIONS Increased transferrin saturation and HFE genotype C282Y/C282Y predict total mortality in patients with late-onset type 1 diabetes, and increased transferrin saturation after diagnosis is an independent risk factor. Early measurement of transferrin saturation in these patients leading to early intervention improves life expectancy. |
| Databáze: | OpenAIRE |
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