Effects of clentiazem (TA-3090) and nifedipine on basal circulating catecholamine levels and on stimulation-evoked adrenal catecholamine secretion in anesthetized dogs
| Autor: | Rania Gaspo, Louis Lamarche, Jacques de Champlain, Nobuharu Yamaguchi, Denis Garceau |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Nifedipine Physiology Blood Pressure Pressoreceptors Baroreflex Clentiazem Norepinephrine (medication) Diltiazem chemistry.chemical_compound Catecholamines Dogs Physiology (medical) Internal medicine Adrenal Glands Reflex Animals Medicine Anesthesia Pharmacology Dose-Response Relationship Drug business.industry Splanchnic Nerves General Medicine Calcium Channel Blockers Electric Stimulation Endocrinology medicine.anatomical_structure Epinephrine chemistry Regional Blood Flow Catecholamine business Adrenal medulla medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 70:983-989 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y92-135 |
| Popis: | The effects of TA-3090 (clentiazem) and nifedipine on basal sympathoadrenal activity and on the adrenal medullary response during splanchnic nerve stimulation were studied in dogs anesthetized with sodium pentobarbital. Plasma concentrations of epinephrine and norepinephrine were measured in aortic and adrenal venous blood before and after acute administration of the drugs, as well as during left splanchnic nerve stimulation before and after administration of drugs. Following intravenous injections, TA-3090 (30, 100, and 300 μg/kg) did not affect basal circulating catecholamine levels, whereas nifedipine (10, 30, and 100 μg/kg) markedly increased aortic epinephrine and norepinephrine concentrations in a dose-dependent manner in correlation with progressive decreases in mean arterial pressure. The changes in aortic epinephrine and norepinephrine concentrations were inversely related to those in mean arterial pressure (r = 0.603, p 2+ channels related to catecholamine release in the adrenal medulla under the present experimental conditions.Key words: calcium antagonists, nifedipine, clentiazem, adrenal gland, catecholamines, splanchnic nerve, baroreflex. |
| Databáze: | OpenAIRE |
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