Anti-pre-S2 antibodies in natural hepatitis B virus infection and after immunization
| Autor: | J.L. Barres, J. P. Chiron, Yves Buisson, B. Yvonnet, Pierre Saliou, Pierre Coursaget, Philippe Adamowicz, Ibrahima Diop Mar, C. Bourdil |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Viral Hepatitis Vaccines
Hepatitis B virus HBsAg Hepatitis B vaccine medicine.disease_cause Antigen Pregnancy Humans Medicine Hepatitis B Vaccines Hepatitis B Antibodies Pregnancy Complications Infectious Protein Precursors Hepatitis B Surface Antigens General Veterinary General Immunology and Microbiology biology business.industry Infant Newborn Public Health Environmental and Occupational Health Infant Hepatitis B biology.organism_classification medicine.disease Virology Infectious Diseases Hepadnaviridae Immunization Carrier State Immunology biology.protein Molecular Medicine Female Antibody business Liver cancer |
| Zdroj: | Vaccine. 6:357-361 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/0264-410x(88)90183-1 |
| Popis: | Anti-pre-S 2 antibodies were detected by enzyme-linked immuno-adsorbant assay using a synthetic peptide analogue of pre-S 2 protein, in different groups of hepatitis-B-infected subjects, including patients presenting with cirrhosis and liver cancer, and also in infants immunized with hepatitis B vaccine. Anti-pre-S 2 antibodies were not detected in hepatitis B surface antigen (HBsAg) chronic carriers, including patients with cirrhosis or primary liver cancer. Anti-pre-S 2 antibodies were not detected in HBsAg-positive sera during the early phase of acute hepatitis. They were only noted upon recovery, when anti-HBs antibodies are detectable at the same time as HBsAg. After recovery, anti-pre-S 2 antibodies were noted in 57% of test sera and were still detectable in 16% of anti-HBs-positive sera obtained years after HBV infection. Anti-pre-S 2 antibodies were detected in 70% of infants immunized with 2 or 5 μg doses of Hevac B Pasteur vaccine, confirming that this vaccine contains pre-S 2 antigen. Anti-pre-S 2 detection was correlated with the anti-HBs antibody titre. |
| Databáze: | OpenAIRE |
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