Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage
| Autor: | Charles B Malpas, Marc L. Seal, Sila Genc, Emma Sciberras, Alisha Gulenc, Timothy J. Silk, Daryl Efron |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Longitudinal study Fmajor forceps major Physiology IFOF inferior fronto-occipital fasciculus FDC fibre density and cross-section Pubertal stage 0302 clinical medicine SLF superior longitudinal fasciculus ADHD attention-deficit/hyperactivity disorder Longitudinal Studies FA fractional anisotropy ILF inferior longitudinal fasciculus PDS pubertal development scale Child Original Research Modelling analysis 05 social sciences lcsh:QP351-495 White matter Age Factors Brain Fibre morphology medicine.anatomical_structure Linear relationship Female FOD fibre orientation distribution Right superior longitudinal fasciculus Psychology Fixel-based analysis Adolescent Cognitive Neuroscience Right inferior longitudinal fasciculus FD fibre density 050105 experimental psychology NICAP Neuroimaging of the Children’s Attention Project Fibre density 03 medical and health sciences medicine Humans FBA fixel-based analysis 0501 psychology and cognitive sciences FC fibre cross-section SES socio-economic status Fx fornix CST cortico-spinal tract Fminor forceps minor Puberty Sexual dimorphism SEIFA Socio-Economic Indexes for Areas lcsh:Neurophysiology and neuropsychology CCH cingulum hippocampus UF uncinate fasciculus CCG cingulum cingulate gyrus Longitudinal CSD constrained spherical deconvolution MRI magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Developmental Cognitive Neuroscience Developmental Cognitive Neuroscience, Vol 45, Iss, Pp 100853-(2020) |
| ISSN: | 1878-9307 1878-9293 |
| Popis: | Highlights • Fibre properties derived from fixel-based analysis are sensitive to development. • Age-related patterns are consistent with previous diffusion tensor studies. • Pubertal stage correlates with fibre density and morphology in the right SLF. • Pubertal stage correlates with fibre morphology in the right ILF. • Pubertal progression interacts with age for longitudinal fibre density changes. The pubertal period involves dynamic white matter development. This period also corresponds with rapid gains in higher cognitive functions including attention, as well as increased risk of developing mental health difficulties. This longitudinal study comprised children aged 9–13 years (n = 130). Diffusion magnetic resonance imaging (dMRI) data were acquired (b = 2800s/mm2, 60 directions) at two time-points. We derived measures of fibre density and morphology using the fixel-based analysis framework and performed a tract-based mixed-effects modelling analysis to understand patterns of white matter development with respect to age, sex, pubertal stage, and the change in pubertal stage. We observed significant increases in apparent fibre density across a large number of white matter pathways, including major association and commissural pathways. We observed a linear relationship between pubertal stage and fibre density and morphology in the right superior longitudinal fasciculus, and fibre morphology in the right inferior longitudinal fasciculus. Finally, we report a significant interaction between the change in pubertal stage and age in the development of fibre density, for left-lateralised association tracts. Overall, white matter development across ages 9–13 years involves the expansion of major white matter fibre pathways, with key association pathways linked with pubertal stage. |
| Databáze: | OpenAIRE |
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