Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics
| Autor: | Justyna Sosna, Shahin Homaeigohar, Moheb Abdelaziz, Mady Elbahri, Duygu Disci-Zayed, Dieter Adam, Ramzy Abdelaziz, Lorenz Kienle, Torben Dankwort |
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| Přispěvatelé: | Department of Chemistry and Materials Science, Kiel University, School services, CHEM, Aalto-yliopisto, Aalto University |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Hot Temperature
Green Chemistry Technology Materials science Cell Survival Science Metal Nanoparticles General Physics and Astronomy Nanoparticle Nanochemistry Nanotechnology Context (language use) 02 engineering and technology 010402 general chemistry 01 natural sciences Leidenfrost effect Article General Biochemistry Genetics and Molecular Biology Cell Line Nanoclusters Jurkat Cells Mice chemistry.chemical_compound Cell Line Tumor Neoplasms Animals Humans Zinc peroxide ta116 Multidisciplinary fungi U937 Cells General Chemistry 021001 nanoscience & nanotechnology Peroxides 0104 chemical sciences Zinc Nanomedicine chemistry Leukocytes Mononuclear 0210 nano-technology HT29 Cells |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters. Such nanoparticles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics. Our research can pave the way for employment of the dynamic green nanochemistry in facile, scalable fabrication of size-tailored nanoparticles for biomedical applications. Water can function as a sustainable reactor for the synthesis of size-controlled, functional nanoparticles. Here, the authors introduce an underwater Leidenfrost synthesis that reproduces the dynamic chemistry of the deep ocean, in which anticancer therapeutic ZnO2 nanoclusters form in an overheated zone and migrate to colder water to continue growth. |
| Databáze: | OpenAIRE |
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