Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function

Autor: Kyong Yeun Jung, Sun Kyoung Han, Hwa Young Ahn, Young Joo Park, Bo Youn Cho, Min Kyong Moon
Rok vydání: 2017
Předmět:
Apolipoprotein E
Adult
Male
endocrine system
medicine.medical_specialty
Thyroid Hormones
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Levothyroxine
Thyroid Gland
Thyrotropin
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Internal medicine
Iodine Isotopes
Internal Medicine
medicine
Humans
Thyroid Neoplasms
Triglycerides
Nutrition and Dietetics
business.industry
Cholesterol
Thyroid
Cholesterol
HDL
Lipid metabolism
Middle Aged
Lipid Metabolism
Endocrinology
medicine.anatomical_structure
Apolipoproteins
chemistry
Thyroidectomy
lipids (amino acids
peptides
and proteins)
Female
Thyroid function
Cardiology and Cardiovascular Medicine
business
Hormone
medicine.drug
Zdroj: Journal of clinical lipidology. 11(6)
ISSN: 1933-2874
Popis: Background Thyroid hormone regulates lipid metabolism. In particular, it has been reported to regulate plasma high-density lipoprotein cholesterol (HDL-C) levels and the activity of molecules involved in HDL metabolism. Objective We investigated changes in the concentrations of lipids and apolipoproteins and in the function of HDL according to acute dynamic changes in thyroid function. Methods Concentrations of plasma lipids and apolipoproteins, paraoxonase-1 activity, and cholesterol efflux were measured in 27 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and radioactive iodine (RAI) treatment, at 3 distinct times: After surgery (baseline subclinical hyperthyroid state), on the day of undergoing RAI treatment (overt hypothyroid state), and 3 months post-RAI treatment (subclinical hyperthyroid state). Results The mean free T4 and thyroid-stimulating hormone concentrations were 0.24 ± 0.06 ng/dL and 91.2 (77.8–118.2) μIU/mL, respectively, on the day of RAI treatment. Total cholesterol, triglyceride, low-density lipoprotein cholesterol, and apoB levels, and the apoA-I/II ratio were significantly increased in the overt hypothyroid state and recovered to baseline values with levothyroxine replacement. HDL-C and apoE levels were persistently elevated despite levothyroxine replacement. Paraoxonase-1 activity, corrected for apoA-I, decreased in the overt hypothyroid state but recovered with levothyroxine replacement ( P = .009). Cholesterol efflux also decreased significantly in the overt hypothyroid state (21.5 ± 5.1% vs 18.9 ± 2.9%, P = .005), but remained low despite recovery of thyroid function. Conclusion Changes in thyroid function are associated not only with changes in the concentrations of various plasma lipid components but also with changes in HDL function.
Databáze: OpenAIRE
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