Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre

Autor:	Tipaya Singhalak, Urarat Nanna, Supaporn Vannasiri, Kanjana Jaijoy, Seewaboon Sireeratawong
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	medicine.medical_specialty Article Subject business.industry Physiology Ziziphus attopensis Body weight Acute toxicity Toxicology Oral administration medicine Histopathology Oral toxicity business Chronic toxicity Oral feeding Research Article
Zdroj:	ISRN Pharmacology
ISSN:	2090-5173 2090-5165
Popis:	We studied an acute and chronic oral toxicity of the extract from Ziziphus attopensis (ZA) in male and female SD rats according to the OECD guidelines. After a single oral administration of ZA 5 g/kg body weight, measurement of the body and organs, necropsy, and health monitoring were performed. The body and organ weights and behavior were not changed relative to the control rats indicating that ZA does not produce acute toxicity. The chronic toxicity was determined by oral feeding both male and female rats daily with ZA at the doses of 1, 2, 4, and 8 g/kg body weight for 180 days. Body weight changes, hematological and biochemical parameters, organ weights, gross finding, and histopathology examination were monitored during the experimental period. The results did not show any differences from the control groups. Analyses of these results with the information of signs, behavior, and health monitoring can lead to a conclusion that the long-term oral administration of ZA for 180 days does not cause chronic toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6beedbe500e9bbc66ca640591f069114 http://europepmc.org/articles/PMC3317065 Zobrazit plný text záznamu