Mentha Rhizomes as an Alternative Source of Natural Antioxidants
| Autor: | Silvia Fialová, Pavel Mučaji, D. Tekeľová, Lucia Jánošová, Elena Kurin, Milan Nagy, Eva Trajčíková, Ivana Šušaníková |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
rosmarinic acid
Antioxidant DPPH medicine.medical_treatment Mentha rhizomes Pharmaceutical Science antioxidant activity 01 natural sciences Article Analytical Chemistry interaction study lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery medicine Physical and Theoretical Chemistry ABTS Traditional medicine 010405 organic chemistry Rosmarinic acid Organic Chemistry food and beverages 0104 chemical sciences Rhizome 010404 medicinal & biomolecular chemistry chemistry Chemistry (miscellaneous) Polyphenol lithospermic acid Molecular Medicine Composition (visual arts) Dose reduction |
| Zdroj: | Molecules Volume 25 Issue 1 Molecules, Vol 25, Iss 1, p 200 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25010200 |
| Popis: | Unlike its aerial parts, the underground parts of Mentha have so far been studied only marginally. By examining the polyphenolic fingerprint, the antioxidant efficacy and the mutual antioxidant behaviour of mixtures of mint rhizomes, our study presents a modest contribution to addressing this gap. Firstly, we examined the composition of the mint rhizomes: Mentha × piperita cv. &lsquo Perpeta&rsquo (MPP), M. longifolia (ML), and M. × villosa cv. &lsquo Snežna&rsquo (MVS). Our LC-MS-DAD analysis revealed the presence of ten compounds belonging to groups of phenolic acids and flavonoids, of which the rosmarinic acid (RA) and lithospermic were most strongly represented. Secondly, we evaluated the antioxidant activity of rhizome infusions by DPPH and ABTS and on NIH/3T3 cell lines by DCFH-DA. Thirdly, we determined, examined, and explained the mutual interactions of rhizome infusions mixtures. While most of the combinations acted additive, synergy was observed in ternary infusion mixtures. The synergic action was also detected in the combination of MPP rhizome infusion and RA in the DCFH-DA test. The combinations of mint rhizomes and rosmarinic acid displayed a high dose-reduction index. This leads to beneficial dose reduction at a given antioxidant effect level in mixtures, compared to the dose of the parts used alone. So far, the pharmaceutical and food industry has not used mint rhizomes in commercial products. Hence, our study draws attention to further applications of the Mentha rhizomes as a valuable alternative source of natural antioxidants. |
| Databáze: | OpenAIRE |
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