Blood Pressure, Hematologic and Erythrocyte Fragility Changes in Children Suffering from Sickle Cell Anemia following Ascorbic Acid Supplementation
| Autor: | S Gbenebitse, Edamisan Temiye, S I Jaja, A R Ikotun |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Anemia Erythrocytes Abnormal Nigeria Blood Pressure Anemia Sickle Cell Ascorbic Acid Hematocrit Internal medicine Fetal hemoglobin Humans Medicine Child Fetal Hemoglobin medicine.diagnostic_test business.industry Erythrocyte fragility Ascorbic acid medicine.disease Surgery Osmotic Fragility Red blood cell Infectious Diseases Endocrinology medicine.anatomical_structure Child Preschool Data Interpretation Statistical Pediatrics Perinatology and Child Health Female Hemoglobin business |
| Zdroj: | Journal of Tropical Pediatrics. 48:366-370 |
| ISSN: | 1465-3664 0142-6338 |
| DOI: | 10.1093/tropej/48.6.366 |
| Popis: | The effect of ascorbic acid supplementation (100 mg/day for 6 weeks) on blood pressure, packed cell volume, irreversibly sickled cells, per cent fetal hemoglobin, hemoglobin concentration, and erythrocyte osmotic fragility was assessed in children suffering from sickle cell anemia. Fifteen children whose ages ranged from 4 to 11 years (7.5 +/- 0.75 years) were studied. Ascorbic acid supplementation reduced systolic blood pressure by 10.9 +/- 3.4 mmHg (p < 0.01), diastolic blood pressure by 7.3 +/- 2.0 mmHg (p < 0.01) and mean arterial pressure by 9.4 +/- 2.6 mmHg (p < 0.01). It significantly increased packed cell volume (p < 0.001), hemoglobin concentration (p < 0.001) and per cent fetal hemoglobin (p < 0.001), but reduced per cent irreversibly sickled cells (p < 0.001). Ascorbic acid supplementation also abolished the long tail of the erythrocyte osmotic fragiligram and increased the resistance of the cells to lysis. |
| Databáze: | OpenAIRE |
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