S15261, A NOVEL AGENT FOR THE TREATMENT OF INSULIN RESISTANCE. STUDIES ON PSAMMOMYS OBESUS
| Autor: | J. Duhault, N. Bennani, J Espinal, T. El Madani, G. Marquié, M.L. Solera, S Khallayoun |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Overweight General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Insulin resistance Hyperinsulinism Internal medicine medicine Animals Insulin General Pharmacology Toxicology and Pharmaceutics Fluorenes biology Cholesterol Body Weight Insulin resistant General Medicine Plasma levels Glucose Tolerance Test medicine.disease biology.organism_classification Lipids Obesity Anti-diabetic Agent Endocrinology chemistry Hyperglycemia Female lipids (amino acids peptides and proteins) Psammomys Insulin Resistance medicine.symptom Gerbillinae |
| Zdroj: | Life Sciences. 61:1741-1753 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(97)00798-4 |
| Popis: | S15261 is a novel compound that has been proposed for the treatment of insulin resistance syndrome. We have studied the effects of this drug in insulin resistant sand rats (Psammomys obesus). When sand rats are transferred from their natural desert environment and placed on a laboratory chow diet, they become overweight, develop hypertriglyceridaemia, hypercholesterolaemia, become insulin resistant, and ultimately diabetic. In the present study glucose intolerant animals, with very mild if any hyperglycaemia were used. Chronic treatment for a month with S15261 normalised plasma levels of triglycerides and cholesterol. The effects on cholesterol were the result of a decrease in LDL- and VLDL-cholesterol without any modification of HDL-cholesterol. In this study only female sand rats showed elevated plasma glucose levels, which were normalised by S15261. The compound also decreased plasma insulin levels both in male and female sand rats. An oral glucose tolerance test showed a major improvement in glucose tolerance in both male and female animals treated with S15261. These data confirm in another animal model the therapeutic benefits of S15261 in insulin resistant states. |
| Databáze: | OpenAIRE |
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