Modulation of intestinal barrier function to ameliorate Salmonella infection in mice by oral administration of fermented milks produced with Lactobacillus plantarum MTCC 5690 – a probiotic strain of Indian gut origin
| Autor: | Namita Rokana, Rashmi Hogarehalli Mallappa, V. K. Batish, Rajbir Singh, Sunita Grover |
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| Rok vydání: | 2016 |
| Předmět: |
Salmonella typhimurium
0301 basic medicine Microbiology (medical) Salmonella Cultured Milk Products 030106 microbiology Administration Oral India Salmonella infection medicine.disease_cause Polymerase Chain Reaction Microbiology law.invention Irritable Bowel Syndrome Feces Mice 03 medical and health sciences Probiotic Oral administration law medicine Animals Food science Intestinal Mucosa Barrier function Mucin-2 Salmonella Infections Animal Intestinal permeability biology Probiotics food and beverages General Medicine biology.organism_classification medicine.disease Intestinal epithelium Toll-Like Receptor 2 Intestines Toll-Like Receptor 4 Disease Models Animal Milk 030104 developmental biology Bacterial Translocation Lactobacillus plantarum |
| Zdroj: | Journal of Medical Microbiology. 65:1482-1493 |
| ISSN: | 1473-5644 0022-2615 |
| Popis: | Probiotic Lactobacillus plantarum MTCC 5690, a probiotic strain of Indian gut origin, and milk formulations produced with the same were explored in this study as biotherapeutics by evaluating their functional efficacy against Salmonella infection in mice. The efficacy of milk formulations (fermented/unfermented) of MTCC 5690 for enhancement of intestinal barrier function was determined by monitoring the permeability and histopathology of the intestine. Infected mice fed with probiotic Dahi, fermented probiotic drink and sweetened fermented probiotic drink maintained the health and integrity of the intestinal epithelium as compared to those fed with PBS, milk, unfermented probiotic milk and Dahi. Our relative expression data revealed that the changes caused by MTCC 5690 in intestinal barrier function components were established through modulation of the key regulatory receptors Toll-like receptor 2 and Toll-like receptor 4. The results suggest that fermented milks of MTCC 5690 could enhance the defences of the intestinal barrier in enteric infection condition and, therefore, can be explored as a dietary-based strategy to reduce Salmonella infection in the human gut. |
| Databáze: | OpenAIRE |
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